A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults.
Artikel i vetenskaplig tidskrift, 2018

Adherence to a low-gluten diet has become increasingly common in parts of the general population. However, the effects of reducing gluten-rich food items including wheat, barley and rye cereals in healthy adults are unclear. Here, we undertook a randomised, controlled, cross-over trial involving 60 middle-aged Danish adults without known disorders with two 8-week interventions comparing a low-gluten diet (2 g gluten per day) and a high-gluten diet (18 g gluten per day), separated by a washout period of at least six weeks with habitual diet (12 g gluten per day). We find that, in comparison with a high-gluten diet, a low-gluten diet induces moderate changes in the intestinal microbiome, reduces fasting and postprandial hydrogen exhalation, and leads to improvements in self-reported bloating. These observations suggest that most of the effects of a low-gluten diet in non-coeliac adults may be driven by qualitative changes in dietary fibres.

Författare

Henrik Munch Roager

Nadja B. Søndertoft

Hansen LBS

Danmarks Tekniske Universitet (DTU)

R. J. Gobel

M. Kristensen

Mireia Vallès-Colomer

Sara Vieira-Silva

Mads Vendelbo Lind

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Rasmus B. Mærkedahl

Sabine Ibrügger

Martin I. Bahl

Jesper Havelund

ML Madsen

Köpenhamns universitet

Inge Tetens

Gwen Falony

Trine Nielsen

Kristine H. Allin

Henrik L. Frandsen

Bolette Hartmann

Jan Holst

Morten H. Sparholt

Jesper Holck

Andreas Blennow

H Moll

A Meyer

Danmarks Tekniske Universitet (DTU)

Camilla Hoppe

Jørgen H. Poulsen

Vera Carvalho

Domenico Sagnelli

Marlene D. Dalgaard

Anna Christensen

Magnus Christian Lydolph

Alastair Ross

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Silas G. Villas-Boas

Susanne Brix

T. Sicheritz-Pontén

Karsten Buschard

Allan Linneberg

Jüri J. Rumessen

Chris Ekstrom

Christian Ritz

Karsten Kristiansen

H. H. Nielsen

Henrik Vestergaard

Nils J. Færgeman

Jeroen Raes

Hanne Frøkiær

T. Hansen

Lotte Lauritzen

Rajiv Gupta

Tine Rask Licht

Oluf Pedersen

Nature Communications

2041-1723 (ISSN)

Vol. 13 9 4630

Infrastruktur

Chalmers infrastruktur för masspektrometri

Ämneskategorier

Livsmedelsvetenskap

Klinisk vetenskap

Näringslära

Fundament

Grundläggande vetenskaper

Styrkeområden

Livsvetenskaper och teknik

DOI

10.1038/s41467-018-07019-x

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Senast uppdaterat

2019-01-18