Formation of a protein corona around nanoparticles
Reviewartikel, 2019

In biofluids, nanoparticles rapidly become surrounded by a protein corona. This phenomenon started to attract attention 10 years ago. Since then, this subfield of colloid and interface science was among the most rapidly expanding and progressing. Owing to its strong relation to biology and applications, this area is rich in various questions to explore. The reviews of the corresponding experiments are already numerous. Herein, I focus on the related theory including conventional mean-field kinetic models, dynamic density functional theory, Monte Carlo simulations, and molecular dynamics simulations. The key concept here is that the formation of a protein corona depends on the interplay of competition of different proteins for the location near the nanoparticle–solution interface (Vroman effect) and denaturation at this interface. Although this concept is not new, many details of this interplay are still open for debate.

Nanoparticles

Models

Protein corona

Protein adsorption

Författare

Vladimir Zhdanov

Russian Academy of Sciences

Chalmers, Fysik, Biologisk fysik

Current Opinion in Colloid and Interface Science

1359-0294 (ISSN)

Vol. 41 95-103

Ämneskategorier

Fysikalisk kemi

Biofysik

Teoretisk kemi

DOI

10.1016/j.cocis.2018.12.002

Mer information

Senast uppdaterat

2019-12-04