Global diffusion limitations during the initial phase of the formation of a protein corona around nanoparticles
Artikel i vetenskaplig tidskrift, 2019

Herein, I illustrate analytically how the global diffusion limitations can influence the first phase of the protein-corona formation at nanoparticles under conditions of intravascular injection. In particular, the concentrations of proteins near the boundaries of the injection region are shown to be comparable with those far from the region. In contrast, the concentrations of proteins inside the injection region may be dramatically smaller than those outside, and the ratio of these two concentrations for proteins of different size may be much higher, by a few orders of magnitude, for smaller proteins. These differences in the spatial distribution of proteins are expected to play a key role in the Vroman effect at the onset of the protein-corona formation.

Nanoparticles

Injection

Protein corona

Diffusion limitations

Författare

Vladimir Zhdanov

Russian Academy of Sciences

Chalmers, Fysik, Biologisk fysik

Journal of Biological Physics

0092-0606 (ISSN) 1573-0689 (eISSN)

Ämneskategorier

Fysikalisk kemi

Cellbiologi

Biofysik

DOI

10.1007/s10867-019-09522-8

Mer information

Senast uppdaterat

2019-04-15