A Whole-Grain Diet Increases Glucose-Stimulated Insulin Secretion Independent of Gut Hormones in Adults at Risk for Type 2 Diabetes
Artikel i vetenskaplig tidskrift, 2019

Introduction: The effect of whole-grain (WG) versus refined-grain (RG) diets on glucose-stimulated insulin secretion (GSIS) and β-cell function is unclear. Methods: In a double-blind crossover randomized controlled trial, 13 prediabetic adults (37.2 ± 1.8 y, BMI: 33.6 ± 1.4 kg m −2 , 2 h glucose: 146.9 ± 11.6 mg dL −1 ) are provided isocaloric-matched WG and RG diets for 8-weeks each, with an 8–10 week washout between diets. Glucose, insulin, and C-peptide are studied over 240 min following a 75 g OGTT. Incretins (GLP-1 and GIP), PYY, and total ghrelin are assessed at 0, 30, and 60 min. Mixed-meal diets for carbohydrate (54%), fat (28%), and protein (18%) contain either WG (50 g/1000 kcal) or equivalent RG. Results: Both diets induce fat loss (≈2 kg). While neither diet impacts early phase GSIS, the WG diet increases total GSIS (iAUC of C-peptide 0-240 /Glc 0-240 , p = 0.02) and β-cell function (disposition index; GSIS × insulin sensitivity, p = 0.02). GIP and PYY are unaltered by either diet, but GLP-1 is higher at 30 min following RG versus WG (p = 0.04). Ghrelin levels are higher at 60 min of the OGTT following both interventions (p = 0.01). Conclusion: A WG-rich diet increases β-cell function independent of gut hormones in adults with prediabetes.

alkylresorcinols

low-glycemic diet

insulin

obesity

glucose tolerance

Författare

Steven K Malin

University of Virginia

Cleveland Clinic Foundation

Emily L Kullman

Cleveland State University

Cleveland Clinic Foundation

Amanda R Scelsi

Cleveland Clinic Foundation

J. P. Godin

Nestle S.A.

Alastair Ross

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

J.P. Kirwan

Cleveland Clinic Foundation

Pennington Biomedical Research Center

Publicerad i

Molecular Nutrition and Food Research

1613-4125 (ISSN) 1613-4133 (eISSN)

Vol. 63 Nummer/häfte 7 art. nr 1800967

Kategorisering

Ämneskategorier (SSIF 2011)

Endokrinologi och diabetes

Annan klinisk medicin

Näringslära

Identifikatorer

DOI

10.1002/mnfr.201800967

Mer information

Senast uppdaterat

2019-04-29