Motions of water and solutes-Slaving versus plasticization phenomena
Artikel i vetenskaplig tidskrift, 2019

It is well-accepted that hydration water is crucial for the structure, dynamics, and function of proteins. However, the exact role of water for the motions and functions of proteins is still debated. Experiments have shown that protein and water dynamics are strongly coupled but with water motions occurring on a considerably faster time scale (the so-called slaving behavior). On the other hand, water also reduces the conformational entropy of proteins and thereby acts as a plasticizer of them. In this work, we analyze the dynamics (using broadband dielectric spectroscopy) of some specific non-biological water solutions in a broad concentration range to elucidate the role of water in the dynamics of the solutes. Our results demonstrate that at low water concentrations (less than 5 wt. %), the plasticization phenomenon prevails for all the materials analyzed. However, at higher water concentrations, two different scenarios can be observed: the slaving phenomenon or plasticization, depending on the solute analyzed. These results generalize the slaving phenomenon to some, but not all, non-biological solutions and allow us to analyze the key factors for observing the slaving behavior in protein solutions as well as to reshaping the slaving concept.

Författare

Izaskun Combarro Palacios

Universidad del Pais Vasco/ Euskal Herriko Unibertsitatea

Christoffer Olsson

Chalmers, Fysik, Biologisk fysik

Christina S. Kamma-Lorger

El Sincrotrón ALBA

Jan Swenson

Chalmers, Fysik, Biologisk fysik

Silvina Cerveni

Universidad del Pais Vasco/ Euskal Herriko Unibertsitatea

Donostia International Physics Center

Journal of Chemical Physics

0021-9606 (ISSN) 1089-7690 (eISSN)

Vol. 150 12 124902

Struktur och dynamik i mjuka och biologiska material. I & II

Vetenskapsrådet (VR), 2016-01-01 -- 2019-12-31.

Vetenskapsrådet (VR), 2012-01-01 -- 2015-12-31.

Ämneskategorier

Fysikalisk kemi

Biofysik

Oceanografi, hydrologi, vattenresurser

DOI

10.1063/1.5030064

PubMed

30927900

Mer information

Senast uppdaterat

2019-07-11