Dietary Polyunsaturated Fatty Acids Promote Neutrophil Accumulation in the Spleen by Altering Chemotaxis and Delaying Cell Death
Artikel i vetenskaplig tidskrift, 2019

Neutrophils are the most abundant circulating leukocytes in humans and are essential for the defense against invading pathogens. Like many other cells of an organism, neutrophils can be highly influenced by the diet. We have previously described that mice fed a high-fat diet rich in polyunsaturated fatty acids (HFD-P) present a higher frequency of neutrophils in bone marrow than mice fed a high-fat diet rich in saturated fatty acids (HFD-S). Interestingly, such an increase correlated with improved survival against bacterium-induced sepsis. In this study, we aimed to investigate the effects of dietary polyunsaturated and saturated fatty acids on neutrophil homeostasis. We found that HFD-P specifically induced the accumulation of neutrophils in the marginal pools of the spleen and liver. The accumulation of neutrophils in the spleen was a result of a dual effect of polyunsaturated fatty acids on neutrophil homeostasis. First, polyunsaturated fatty acids enhanced the recruitment of neutrophils from the circulation into the spleen via chemokine secretion. Second, they delayed neutrophil cell death in the spleen. Interestingly, these effects were not observed in mice fed a diet rich in saturated fatty acids, suggesting that the type of fat rather than the amount of fat mediates the alterations in neutrophil homeostasis. In conclusion, our results show that dietary polyunsaturated fatty acids have a strong modulatory effect on neutrophil homeostasis that may have future clinical applications.

polyunsaturated fatty acids

dietary fatty acids

neutrophils

apoptosis

chemotaxis

Författare

Sara L. Svahn

Göteborgs universitet

Saray Gutierrez

Göteborgs universitet

Marcus A. Ulleryd

Göteborgs universitet

Intawat Nookaew

Chalmers, Biologi och bioteknik, Systembiologi

Veronica Osla

Göteborgs universitet

Fredrik Beckman

Göteborgs universitet

Staffan Nilsson

Göteborgs universitet

Anna Karlsson

Göteborgs universitet

John-Olov Jansson

Göteborgs universitet

Maria E. Johansson

Göteborgs universitet

Infection and Immunity

0019-9567 (ISSN) 1098-5522 (eISSN)

Vol. 87 8 e00270-19

Ämneskategorier

Cell- och molekylärbiologi

Immunologi inom det medicinska området

Näringslära

DOI

10.1128/IAI.00270-19

PubMed

31085706

Mer information

Senast uppdaterat

2019-10-03