Hyperthermia treatment planning including convective flow in cerebrospinal fluid for brain tumour hyperthermia treatment using a novel dedicated paediatric brain applicator
Artikel i vetenskaplig tidskrift, 2019

Hyperthermia therapy (40–44 °C) is a promising option to increase efficacy of radiotherapy/chemotherapy for brain tumours, in particular paediatric brain tumours. The Chalmers Hyperthermia Helmet is developed for this purpose. Hyperthermia treatment planning is required for treatment optimisation, but current planning systems do not involve a physically correct model of cerebrospinal fluid (CSF). This study investigates the necessity of fluid modelling for treatment planning. We made treatments plans using the Helmet for both pre-operative and post-operative cases, comparing temperature distributions predicted with three CSF models: A convective “fluid” model, a non-convective “solid” CSF model, and CSF models with increased effective thermal conductivity (“high-k”). Treatment plans were evaluated by T90, T50 and T10 target temperatures and treatment-limiting hot spots. Adequate heating is possible with the helmet. In the pre-operative case, treatment plan quality was comparable for all three models. In the post-operative case, the high-k models were more accurate than the solid model. Predictions to within ±1 °C were obtained by a 10–20-fold increased effective thermal conductivity. Accurate modelling of the temperature in CSF requires fluid dynamics, but modelling CSF as a solid with enhanced effective thermal conductivity might be a practical alternative for a convective fluid model for many applications.

Treatment planning

Brain malignancies

Hyperthermia treatment

Cerebrospinal fluid


Computational fluid dynamics


Gerben Schooneveldt

Universiteit Van Amsterdam

Hana Dobsicek Trefna

Chalmers, Elektroteknik, Signalbehandling och medicinsk teknik

Mikael Persson

Chalmers, Elektroteknik, Signalbehandling och medicinsk teknik

Theo De Reijke

Universiteit Van Amsterdam

K. Blomgren

Karolinska Institutet

Karolinska universitetssjukhuset

Petra Kok

Universiteit Van Amsterdam

Hans Crezee

Universiteit Van Amsterdam


20726694 (eISSN)

Vol. 11 8 1183




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