Whey Protein Combined with Low Dietary Fiber Improves Lipid Profile in Subjects with Abdominal Obesity: A Randomized, Controlled Trial
Artikel i vetenskaplig tidskrift, 2019

Abdominal obesity is associated with elevated postprandial triglycerides (TG), an independent risk factor for cardiovascular diseases. Previous studies show that whey protein (WP) and dietary fiber may separately reduce postprandial TG. However, few studies have investigated the long-term effects of WP and dietary fiber on postprandial TG. We aimed to investigate the separate and combined long-term effects of WP and dietary fiber from wheat bran on postprandial TG and markers of lipid metabolism in subjects with abdominal obesity. We conducted a 12-week, double-blind, randomized, controlled, parallel intervention study. In a 2 × 2 factorial design, 73 adults were randomized to receive 60 g/day of either WP hydrolysate or maltodextrin (MD) combined with high-fiber wheat bran products (HiFi; 30 g dietary fiber/day) or low-fiber refined wheat products (LoFi; 10 g dietary fiber/day). A high-fat meal test was conducted before and after the intervention. Sixty-five subjects were included in the final analyses. There were no differences between intervention groups in postprandial TG assessed as incremental area under the curve (iAUC). WP-LoFi had reduced postprandial TG assessed as total area under the curve (tAUC) and reduced fasting TG compared with all other groups, and reduced fasting apolipoprotein B-48 compared with MD-LoFi. There were no changes in lipoprotein lipase activity. Total cholesterol and apolipoprotein B-100 were reduced after WP intake compared with MD. Total cholesterol was increased after HiFi intake compared with LoFi. In conclusion, intake of WP in combination with low-fiber cereal products for 12 weeks had beneficial effects on postprandial TG tAUC and fasting TG, but not on postprandial TG iAUC in subjects with abdominal obesity. Combining WP with high-fiber wheat bran products did not improve lipid profile.

postprandial lipemia

dietary fiber

triglycerides

whey protein

abdominal obesity

Författare

Elin Rakvaag

Arhus Universitetshospital

Rasmus Fuglsang-Nielsen

Arhus Universitetshospital

Knud Erik Bach Knudsen

Aarhus Universitet

Rikard Landberg

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Astrid Johannesson Hjelholt

Arhus Universitetshospital

Esben Søndergaard

Arhus Universitetshospital

Kjeld Hermansen

Aarhus Universitet

Arhus Universitetshospital

Søren Gregersen

Steno Diabetes Center

Arhus Universitetshospital

Nutrients

2072-6643 (ISSN)

Vol. 11 9

Ämneskategorier

Annan klinisk medicin

Livsmedelsvetenskap

Näringslära

DOI

10.3390/nu11092091

PubMed

31487806

Mer information

Senast uppdaterat

2019-11-08