CMY-1/MOX-family AmpC β-lactamases MOX-1, MOX-2 and MOX-9 were mobilized independently from three Aeromonas species
Artikel i vetenskaplig tidskrift, 2019

© 2019 The Author(s) 2019. Objectives: To investigate the origin of CMY-1/MOX-family β-lactamases. Methods: Publicly available genome assemblies were screened for CMY-1/MOX genes. The loci of CMY-1/MOX genes were compared with respect to synteny and nucleotide identity, and subjected to phylogenetic analysis. Results: The chromosomal ampC genes of several Aeromonas species were highly similar to known mobile CMY-1/MOX variants. Annotation and sequence comparison revealed nucleotide identities >98% and conserved syntenies between MOX-1-, MOX-2- and MOX-9-associated mobile sequences and the chromosomal Aeromonas sanarellii, Aeromonas caviae and Aeromonas media ampC loci. Furthermore, the phylogenetic analysis showed that MOX-1, MOX-2 and MOX-9 formed three distinct monophyletic groups with the chromosomal ampC genes of A. sanarellii, A. caviae and A. media, respectively. Conclusions: Our findings show that three CMY-1/MOX-family β-lactamases were mobilized independently from three Aeromonas species and hence shine new light on the evolution and emergence of mobile antibiotic resistance genes.

Författare

Stefan Ebmeyer

Center for Antibiotic Resistance Research

Göteborgs universitet

Erik Kristiansson

Center for Antibiotic Resistance Research

Chalmers, Matematiska vetenskaper, Tillämpad matematik och statistik

D. G. Joakim Larsson

Göteborgs universitet

Center for Antibiotic Resistance Research

Journal of Antimicrobial Chemotherapy

0305-7453 (ISSN) 1460-2091 (eISSN)

Vol. 74 5 1202-1206 dkz025

Ämneskategorier

Biologisk systematik

Medicinsk genetik

Genetik

DOI

10.1093/jac/dkz025

PubMed

30753583

Mer information

Senast uppdaterat

2019-09-23