Systems biology based drug repositioning for development of cancer therapy
Reviewartikel, 2019

Drug repositioning is a powerful method that can assists the conventional drug discovery process by using existing drugs for treatment of a disease rather than its original indication. The first examples of repurposed drugs were discovered serendipitously, however data accumulated by high-throughput screenings and advancements in computational biology methods have paved the way for rational drug repositioning methods. As chemotherapeutic agents have notorious side effects that significantly reduce quality of life, drug repositioning promises repurposed noncancer drugs with little or tolerable adverse effects for cancer patients. Here, we review current drug-related data types and databases including some examples of web-based drug repositioning tools. Next, we describe systems biology approaches to be used in drug repositioning for effective cancer therapy. Finally, we highlight examples of mostly repurposed drugs for cancer treatment and provide an overview of future expectations in the field for development of effective treatment strategies.

Drug repositioning

Signature-based approaches

Network-based approaches

Cancer

Systems biology

Författare

Beste Turanli

İstanbul Medeniyet Üniversitesi

Kungliga Tekniska Högskolan (KTH)

Marmara Universitesi

Ozlem Altay

Kungliga Tekniska Högskolan (KTH)

Jan Borén

Sahlgrenska universitetssjukhuset

Hasan Turkez

Erzurum Teknik Üniversitesi

Jens B Nielsen

Chalmers, Biologi och bioteknik, Systembiologi

Mathias Uhlen

Kungliga Tekniska Högskolan (KTH)

Kazim Y. Arga

Marmara Universitesi

Adil Mardinoglu

Kungliga Tekniska Högskolan (KTH)

King's College London

Seminars in Cancer Biology

1044-579X (ISSN) 1096-3650 (eISSN)

Vol. in press

Ämneskategorier

Farmaceutisk vetenskap

Biomedicinsk laboratorievetenskap/teknologi

Samhällsfarmaci och klinisk farmaci

DOI

10.1016/j.semcancer.2019.09.020

PubMed

31568815

Mer information

Senast uppdaterat

2019-11-28