Interactions between Lipases and Amphiphiles at Interfaces
Artikel i vetenskaplig tidskrift, 2019

This review deals with interactions at interfaces between lipases and low molecular weight amphiphiles, such as polar lipids and synthetic surfactants. The interaction between polar lipids and lipases is particularly important in the gastrointestinal tract, where fat is digested by gastric lipases in the stomach and by pancreatic lipases in the duodenum. Polar lipids have been found to influence lipase activity in numerous ways. For example, it has been found that Sn-2 monoacylglycerols, which are the main degradation products from fat metabolism, take over at the triacylglycerol oil-water interface and prevent further access of the lipase to its substrate, i.e., triacylglycerols and diacylglycerols. Additionally, different types of surfactants interact differently with lipases and the interaction can result in loss of enzymatic activity. As both lipases and the surfactants are strongly surface active, this type of interaction preferentially takes place at an interface. Lipase-surfactant interactions have been systematically studied at the air-water, the solid-water, and the oil-water interfaces. In general, it is found that cationic surfactants interact stronger than anionic or nonionic surfactants at all interfaces but not in bulk water. However, somewhat contradictory results have been reported in the literature and it is likely that the inconsistency is due to the fact that lipases of different origins are used in the different studies.

Amphiphile

Lipase

Fat digestion

Enzymatic activity

Monoacylglycerol

Interaction

Surfactant

Författare

Pedro Reis

UCB Farchim

Martin Malmsten

Köpenhamns universitet

Uppsala universitet

Magnus Nyden

Nouryon AB

Britta Folmer

Nestle Nespresso

Krister Holmberg

Chalmers, Kemi och kemiteknik, Tillämpad kemi

Journal of Surfactants and Detergents

1097-3958 (ISSN)

Vol. 22 5 1047-1058

Ämneskategorier

Fysikalisk kemi

Livsmedelsteknik

Biokatalys och enzymteknik

DOI

10.1002/jsde.12254

Mer information

Senast uppdaterat

2019-11-11