Voluntary and tremorogenic inputs to motor neuron pools of agonist/antagonist muscles in essential tremor patients
Artikel i vetenskaplig tidskrift, 2019

Pathological tremor is an oscillation of body parts at 3-10 Hz, determined by the output of spinal motor neurons (MNs), which receive synaptic inputs from supraspinal centers and muscle afferents. The behavior of spinal MNs during tremor is not well understood, especially in relation to the activation of the multiple muscles involved. Recent studies on patients with essential tremor have shown that antagonist MN pools receive shared input at the tremor frequency. In this study, we investigated the synaptic inputs related to tremor and voluntary movement, and their coordination across antagonist muscles. We analyzed the spike trains of motor units (MUs) identified from high-density surface electromyography from the forearm extensor and flexor muscles in 15 patients with essential tremor during postural tremor. The shared synaptic input was quantified by coherence and phase difference analysis of the spike trains. All pairs of spike trains in each muscle showed coherence peaks at the voluntary drive frequency (1-3 Hz. 0.2 +/- 0.2, mean +/- SI)) and tremor frequency (3-10 Hz, 0.6 +/- 0.3) and were synchronized with small phase differences (3.3 +/- 25.2 degrees and 3.9 +/- 22.0 degrees for the voluntary drive and tremor frequencies. respectively). The coherence between MN spike trains of antagonist muscle groups at the tremor frequency was significantly smaller than intramuscular coherence. We predominantly observed in-phase activation of MUs between agonist/antagonist muscles at the voluntary frequency band (0.6 +/- 48.8 degrees) and out-of-phase activation at the tremor frequency band (126.9 +/- 75.6 degrees). Thus MNs innervating agonist/antagonist muscles concurrently receive synaptic inputs with different phase shifts in the voluntary and tremor frequency bands. NEW & NOTEWORTHY Although the mechanical characteristics of tremor have been widely studied, the activation of the affected muscles is still poorly understood. We analyzed the behavior of motor units of pairs of antagonistic wrist muscle groups in patients with essential tremor and studied their activity at voluntary movement- and tremor-related frequencies. We found that the phase relation between inputs to antagonistic muscles is different at the voluntary and tremor frequency bands.

essential tremor

motor units

neural drive

EMG

voluntary control

coherence

Författare

Gonthicha Puttaraksa

Imperial College London

Silvia Muceli

Chalmers, Elektroteknik, Signalbehandling och medicinsk teknik, Medicinska signaler och system

Juan Alvaro Gallego

Spanish Natl Res Council

Ales Holobar

Univerza v Mariboru

Steven K. Charles

Brigham Young University

Jose L. Pons

Northwestern Univ, McCormick Sch Engn, Dept Mech Engn

Shirley Ryan AbilityLab, Legs & Walking AbilityLab

Spanish Natl Res Council

Northwestern Univ, McCormick Sch Engn, Dept Biomed Engn

Northwestern Univ, Feinberg Sch Med, Dept Phys Med & Rehabil

Dario Farina

Imperial College London

Journal of Neurophysiology

0022-3077 (ISSN) 1522-1598 (eISSN)

Vol. 122 5 2043-2053

Ämneskategorier

Idrottsvetenskap

Neurovetenskaper

Fysiologi

DOI

10.1152/jn.00407.2019

PubMed

31509467

Mer information

Senast uppdaterat

2020-04-20