Quantitative Grafting for Structure-Function Establishment: Thermoresponsive Poly(alkylene oxide) Graft Copolymers Based on Hyaluronic Acid and Carboxymethylcellulose
Artikel i vetenskaplig tidskrift, 2019

© 2019 American Chemical Society. A series of thermoresponsive graft copolymers, gelling at physiological conditions in aqueous solution and cell growth media, have been synthesized using quantitative coupling between a small set of amino-functionalized poly(alkylene oxide) copolymers (PAO) and the carboxylate of the biologically important polysaccharides (PSa) carboxymethylcellulose and the less reactive hyaluronate. Quantitative grafting enables the establishment of structure-function relationship which is imperative for controlling the properties of in situ gelling hydrogels. The EDC/NHS-mediated reaction was monitored using SEC-MALLS, which revealed that all PAOs were grafted onto the PSa backbone. Aqueous solutions of the graft copolymers were Newtonian fluids at room temperatures and formed reversible physical gels at elevated temperatures which were noncytotoxic toward chondrocytes. The established structure-function relationship was most clearly demonstrated by inspecting the thermogelling strength and the onset of thermogelling in a phase diagram. The onset of the thermogelling function could be controlled by the global PAO concentration, independent of graft ratio.


Markus Andersson Trojer


Mats Andersson

Flinders University

Chalmers, Kemi och kemiteknik, Tillämpad kemi

Johan Bergenholtz

Göteborgs universitet

Paul Gatenholm

Chalmers, Kemi och kemiteknik, Tillämpad kemi


1525-7797 (ISSN) 1526-4602 (eISSN)

Vol. 20 3 1271-1280



Fysikalisk kemi






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