Spatio-temporal aspects of the interplay of cancer and the immune system
Artikel i vetenskaplig tidskrift, 2019

The conventional mean-field kinetic models describing the interplay of cancer and the immune system are temporal and predict exponential growth or elimination of the population of tumour cells provided their number is small and their effect on the immune system is negligible. More complex kinetics are associated with non-linear features of the response of the immune system. The generic model presented in this communication takes into account that the rates of the birth and death of tumour cells inside a tumour spheroid can significantly depend on the radial coordinate due to diffusion limitations in the supply of nutrients and/or transport of the species (cells and proteins) belonging to the immune system. In this case, non-trivial kinetic regimes are shown to be possible even without appreciable perturbation of the immune system.

Growth

Tumour

Kinetic model

Cancer

Diffusion

Författare

Vladimir Zhdanov

Chalmers, Fysik, Biologisk fysik

Journal of Biological Physics

0092-0606 (ISSN) 1573-0689 (eISSN)

Vol. 45 4 395-400

Ämneskategorier

Biomedicinsk laboratorievetenskap/teknologi

Annan medicinsk bioteknologi

Inbäddad systemteknik

DOI

10.1007/s10867-019-09535-3

PubMed

31773382

Mer information

Senast uppdaterat

2020-03-02