Graphene-based biosensors for the detection of prostate cancer protein biomarkers: a review
Inledande text i tidskrift, 2019

Prostate cancer (PC) is the sixth most common cancer type in the world, which causes approximately 10% of total cancer fatalities. The detection of protein biomarkers in body fluids is the key topic for the diagnosis and prognosis of PC. Highly sensitive screening of PC is the most effective approach for reducing mortality. Thus, there are a growing number of literature that recognizes the importance of new technologies for early diagnosis of PC. Graphene is playing an important role in the biosensor field with remarkable physical, optical, electrochemical and magnetic properties. Many recent studies demonstrated the potential of graphene materials for sensitive detection of protein biomarkers. In this review, the graphene-based biosensors toward PC analysis are mainly discussed in two groups: Firstly, novel biosensor interfaces were constructed through the modification of graphene materials onto sensor surfaces. Secondly, ingenious signal amplification strategies were developed using graphene materials as catalysts or carriers. Graphene-based biosensors have exhibited remarkable performance with high sensitivities, wide detection ranges, and long-term stabilities.

Graphene

Prostate cancer

Protein biomarker

Biosensor

Författare

Li Xu

Chalmers, Biologi och bioteknik, Systembiologi

Shanghai Institute of Measurement and Testing Technology

Yanli Wen

Shanghai Institute of Measurement and Testing Technology

Santosh Pandit

Chalmers, Biologi och bioteknik, Systembiologi

Venkata Raghavendra Subrahmanya Sar Mokkapati

Chalmers, Kemi och kemiteknik, Energi och material, Oorganisk miljökemi 2

Ivan Mijakovic

Novo Nordisk Foundation Center for Biosustainability

Chalmers, Biologi och bioteknik, Systembiologi

Yan Li

Shanghai Institute of Measurement and Testing Technology

Min Ding

Shanghai Institute of Measurement and Testing Technology

Shuzhen Ren

Shanghai Institute of Measurement and Testing Technology

Wen Li

Shanghai Institute of Measurement and Testing Technology

Gang Liu

Shanghai Institute of Measurement and Testing Technology

BMC CHEMISTRY

2661-801X (eISSN)

Vol. 13 1 UNSP 112

Ämneskategorier

Analytisk kemi

Urologi och njurmedicin

Cancer och onkologi

DOI

10.1186/s13065-019-0611-x

PubMed

31508598

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Senast uppdaterat

2021-04-01