Graphene-based biosensors for the detection of prostate cancer protein biomarkers: a review
Other text in scientific journal, 2019
Prostate cancer (PC) is the sixth most common cancer type in the world, which causes approximately 10% of total cancer fatalities. The detection of protein biomarkers in body fluids is the key topic for the diagnosis and prognosis of PC. Highly sensitive screening of PC is the most effective approach for reducing mortality. Thus, there are a growing number of literature that recognizes the importance of new technologies for early diagnosis of PC. Graphene is playing an important role in the biosensor field with remarkable physical, optical, electrochemical and magnetic properties. Many recent studies demonstrated the potential of graphene materials for sensitive detection of protein biomarkers. In this review, the graphene-based biosensors toward PC analysis are mainly discussed in two groups: Firstly, novel biosensor interfaces were constructed through the modification of graphene materials onto sensor surfaces. Secondly, ingenious signal amplification strategies were developed using graphene materials as catalysts or carriers. Graphene-based biosensors have exhibited remarkable performance with high sensitivities, wide detection ranges, and long-term stabilities.
Graphene
Prostate cancer
Biosensor
Protein biomarker
Author
Li Xu
Shanghai Institute of Measurement and Testing Technology
Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology
Yanli Wen
Shanghai Institute of Measurement and Testing Technology
Santosh Pandit
Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology
Venkata Raghavendra Subrahmanya Sar Mokkapati
Chalmers, Chemistry and Chemical Engineering, Energy and Material
Ivan Mijakovic
Novo Nordisk Foundation
Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology
Yan Li
Shanghai Institute of Measurement and Testing Technology
Min Ding
Shanghai Institute of Measurement and Testing Technology
Shuzhen Ren
Shanghai Institute of Measurement and Testing Technology
Wen Li
Shanghai Institute of Measurement and Testing Technology
Gang Liu
Shanghai Institute of Measurement and Testing Technology
BMC Chemistry
2661801X (eISSN)
Vol. 13 1 UNSP 112Subject Categories
Analytical Chemistry
Urology and Nephrology
Cancer and Oncology
DOI
10.1186/s13065-019-0611-x
PubMed
31508598