Stress-induced expression is enriched for evolutionarily young genes in diverse budding yeasts
Artikel i vetenskaplig tidskrift, 2020
The Saccharomycotina subphylum (budding yeasts) spans 400 million years of evolution and includes species that thrive in diverse environments. To study niche-adaptation, we identify changes in gene expression in three divergent yeasts grown in the presence of various stressors. Duplicated and non-conserved genes are significantly more likely to respond to stress than genes that are conserved as single-copy orthologs. Next, we develop a sorting method that considers evolutionary origin and duplication timing to assign an evolutionary age to each gene. Subsequent analysis reveals that genes that emerged in recent evolutionary time are enriched amongst stress-responsive genes for each species. This gene expression pattern suggests that budding yeasts share a stress adaptation mechanism, whereby selective pressure leads to functionalization of young genes to improve growth in adverse conditions. Further characterization of young genes from species that thrive in harsh environments can inform the design of more robust strains for biotechnology.
Systems analysis
Industrial microbiology
Applied microbiology
Författare
Tyler Doughty
Novo Nordisk Fonden
Chalmers, Biologi och bioteknik, Systembiologi
Iván Domenzain Del Castillo Cerecer
Novo Nordisk Fonden
Chalmers, Biologi och bioteknik, Systembiologi
Aaron Millan-Oropeza
Université Paris-Saclay
Noemi Montini
APC Microbiome Ireland
Philip A. de Groot
TU Delft
Rui Pereira
Novo Nordisk Fonden
Chalmers, Biologi och bioteknik, Systembiologi
Jens B Nielsen
Novo Nordisk Fonden
Chalmers, Biologi och bioteknik, Systembiologi
Céline Henry
Université Paris-Saclay
J. M. Daran
TU Delft
Verena Siewers
Novo Nordisk Fonden
Chalmers, Biologi och bioteknik, Systembiologi
John P. Morrissey
APC Microbiome Ireland
Nature Communications
2041-1723 (ISSN) 20411723 (eISSN)
Vol. 11 1 2144Ämneskategorier
Evolutionsbiologi
Bioinformatik och systembiologi
Genetik
DOI
10.1038/s41467-020-16073-3