Competitive multivalent coadsorption and desorption of biological nanoparticles on a supported lipid bilayer

Artikel i vetenskaplig tidskrift, 2020

The interaction of biological nanoparticles (e.g., similar to 100-nm-sized vesicles, micelles, and virions) with a lipid membrane is often multivalent and may include competition for receptors in situations when attachment of nanoparticles of one type occurs in parallel or is followed by attachment of nanoparticles of the other type. The nanoparticles adsorbed afterwards can induce detachment of the earlier adsorbed nanoparticles. I scrutinize theoretically this scenario in the case of a supported lipid bilayer. The corresponding kinetics are shown to be relatively gradual despite multiple bonds of each nanoparticle with receptors. In addition, the kinetics may exhibit a distinct lag phase.