Controlled drug release by the pore structure in polydimethylsiloxane transdermal patches
Artikel i vetenskaplig tidskrift, 2020

The use of polydimethylsiloxanes (PDMS) as a drug carrier in transdermal adhesive patches is limited and there is insufficient data on the polymer structure and diffusivity, especially when additives modify the matrix. PDMS films with liquid additives (10% w/w): silicone oil (SO), polyoxyethylene glycol (PEG) or propylene glycol (PG) were prepared and indomethacin (IND; 5% w/w) was incorporated as a model active substance. The microstructure of the PDMS matrix and its permeability to water was investigated and correlated to the kinetics of the in-vitro IND release from the film. Three microscopic techniques were used to characterize in detail the microstructure of PDMS films: scanning electron microscopy, fluorescent microscopy and atomic force microscopy. PDMS films with hydrophilic PEG or PG showed different two-phase structures. A two-fold increase in steady-state flux of IND and increased water transport in the presence of PEG was attributed to the pore-like channels created by this polar solvent in the PDMS matrix. This effect was not observed in the films with PG, where only discontinuous droplet-like structures were visible. All additives significantly changed the tensile parameters of the films but the effects were not very pronounced.

Microstructure

Drug release

Transdermal patch

Silicone

Indomethacin

Permeability

Författare

Barbara Mikolaszek

Gdanski Uniwersytet Medyczny

Jurgita Kazlauske

SuMo Biomaterials

Chalmers, Kemi och kemiteknik, Tillämpad kemi, Farmaceutisk teknologi

AstraZeneca AB

Anette Larsson

Chalmers, Kemi och kemiteknik, Tillämpad kemi, Anette Larsson Group

SuMo Biomaterials

Małgorzata Sznitowska

Gdanski Uniwersytet Medyczny

Polymers

2073-4360 (eISSN)

Vol. 12 7 1-16 1520

Ämneskategorier

Polymerkemi

Polymerteknologi

Annan kemi

DOI

10.3390/polym12071520

Mer information

Senast uppdaterat

2020-08-18