Multitarget Approaches against Multiresistant Superbugs
Reviewartikel, 2020

Despite efforts to develop new antibiotics, antibacterial resistance still develops too fast for drug discovery to keep pace. Often, resistance against a new drug develops even before it reaches the market. This continued resistance crisis has demonstrated that resistance to antibiotics with single protein targets develops too rapidly to be sustainable. Most successful long-established antibiotics target more than one molecule or possess targets, which are encoded by multiple genes. This realization has motivated a change in antibiotic development toward drug candidates with multiple targets. Some mechanisms of action presuppose multiple targets or at least multiple effects, such as targeting the cytoplasmic membrane or the carrier molecule bactoprenol phosphate and are therefore particularly promising. Moreover, combination therapy approaches are being developed to break antibiotic resistance or to sensitize bacteria to antibiotic action. In this Review, we provide an overview of antibacterial multitarget approaches and the mechanisms behind them.

antibiotic combination therapy

polypharmacology

synergy

multifunctional antibiotic

multiresistant bacteria

Författare

Declan Alan Gray

Newcastle University

Michaela Wenzel

Chalmers, Biologi och bioteknik, Kemisk biologi

ACS Infectious Diseases

2373-8227 (eISSN)

Vol. 6 6 1346-1365

Antibiotika-inducerad frisättning av aminosyror: en ny strategi för antimikrobiell terapi?

Vetenskapsrådet (VR), 2020-01-01 -- 2023-12-31.

Ämneskategorier

Farmaceutisk vetenskap

Infektionsmedicin

Mikrobiologi inom det medicinska området

DOI

10.1021/acsinfecdis.0c00001

PubMed

32156116

Mer information

Senast uppdaterat

2020-10-13