Quantification of True Lumen Helical Morphology and Chirality in Type B Aortic Dissections
Artikel i vetenskaplig tidskrift, 2020

Chirality is a fundamental property in many biologic systems. Motivated by previous observations of helical aortic blood flow, aortic tissue fibers, and propagation of aortic dissections, we introduce methods to characterize helical morphology of aortic dissections. After validation on computer generated phantoms, the methods were applied to patients with type B dissection. For this cohort, there was a distinct bimodal distribution of helical propagation of the dissection with either achiral or exclusively right-handed chirality, with no intermediate cases or left-handed cases. This clear grouping indicates that dissection propagation favors these two modes, potentially due to the right-handedness of helical aortic blood flow and cell orientation. The characterization of dissection chirality and quantification of helical morphology advances our understanding of dissection pathology and lays a foundation for applications in clinical research and treatment practice. For example, the chirality and magnitude of helical metrics of dissections may indicate risk of dissection progression, help define treatment and surveillance strategies, and enable development of novel devices that account for various helical morphologies.

Författare

Johan Bondesson

Chalmers, Mekanik och maritima vetenskaper, Dynamik

Ga-Young Suh

Torbjörn Lundh

Chalmers, Matematiska vetenskaper, Tillämpad matematik och statistik

Michael D. Dake

Jason T. Lee

Christopher P. Cheng

American Journal of Physiology - Heart and Circulatory Physiology

0363-6135 (ISSN) 1522-1539 (eISSN)

Ämneskategorier

Medicinsk laboratorie- och mätteknik

Medicinteknik

Fysiologi

DOI

10.1152/ajpheart.00778.2020

Mer information

Skapat

2021-01-05