Mass spectrometric imaging of plasma membrane lipid alteration correlated with amperometrically measured activity-dependent plasticity in exocytosis
Artikel i vetenskaplig tidskrift, 2020

The mechanism of synaptic plasticity and its link to memory formation are of interest, yet relatively obscure, especially the initial chemical change in the cell membrane following transmitter release. To understand the chemical mechanism of plasticity, we studied how repetitive stimuli regulate certain membrane lipid species to enhance exocytotic release using mass spectrometric imaging. We found that increasing high-curvature lipid species and decreasing low-curvature lipids in the cell membrane favor the formation of a longer-lasting exocytotic fusion pore, resulting in higher release fraction for individual exocytotic events. The lipid changes observed following repetitive stimuli are similar to those after exposure to the cognitive enhancing drug, methylphenidate, examined in a previous study, and offer an interesting point of view regarding the link between plasticity and memory and cognition.

Repetitive stimuli

Mass spectrometry imaging


Lipid alteration



Chaoyi Gu

Göteborgs universitet

Thuy Mai Hoang Philipsen

Chalmers, Kemi och kemiteknik, Kemi och biokemi

Andrew Ewing

Göteborgs universitet

International Journal of Molecular Sciences

16616596 (ISSN) 14220067 (eISSN)

Vol. 21 24 1-10 9519



Biokemi och molekylärbiologi

Farmakologi och toxikologi





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