Towards UWB microwave hyperthermia for brain cancer treatment
In this thesis, we explore whether the current treatment planning methods can be meaningfully translated to the UWB setting and propose new solutions for UWB microwave hyperthermia. We analyze the most commonly used cost-functions for treatment planning optimization and discuss their suitability for use with UWB systems. Then, we propose a novel cost-function specifically tailored for UWB optimization (HCQ). To solve for the HCQ, we further describe a novel, time-reversal based, iterative scheme for the rapid and efficient optimization of UWB treatment plans. We show that the combined use of these techniques results in treatment plans that better exploit the benefits of UWB systems, yielding increased tumor coverage and lower peak temperatures outside the target. Next, we investigate the design possibilities of UWB applicators and introduce a fast E-field approximation scheme. The method can be used for the global optimization of the array parameters with respect to the multiple objectives and requirements of hyperthermia treatments. Together, the proposed solutions represent a step forward in the implementation of patient-specific hyperthermia treatments, increasing their accuracy and precision. The results suggest that UWB microwave hyperthermia for brain cancer treatment is feasible, and motivate the efforts for further development of UWB applicators and systems.
Chalmers, Elektroteknik, Signalbehandling och medicinsk teknik
Suitability of eigenvalue beamforming for discrete multi-frequency hyperthermia treatment planning
Combining target coverage and hot-spot suppression into one cost function: the hot-to-cold spot quotient
Iterative time-reversal for multi-frequency hyperthermia
Optimization of microwave hyperthermia array applicators using field interpolation
2019 IEEE International Symposium on Antennas and Propagation and USNC-URSI Radio Science Meeting, APSURSI 2019 - Proceedings,; (2019)p. 537-538
Paper i proceeding
Mikrovågs Hypertermi för cancerbehandling
Barncancerfonden, 2012-01-01 -- .
Cancer och onkologi
Hälsa och teknik
Opponent: Petra H. Kok, Department of Radiation Oncology, Amsterdam University Medical Center (UMC), The Netherlands