Melting transition of oriented Li-DNA fibers submerged in ethanol solutions
Artikel i vetenskaplig tidskrift, 2021

The melting transition of Li-DNA fibers immersed in ethanol-water solutions has been studied using calorimetry and neutron diffraction techniques. The data have been analyzed using the Peyrard-Bishop-Dauxois model to determine the strengths of the intra- and inter-base pair potentials. The data and analysis show that the potentials are weaker than those for DNA in water. They become weaker still and the DNA less stable as the ethanol concentration increases but, conversely, the fibers become more compact and the distances between base pairs become more regular. The results show that the melting transition is relatively insensitive to local confinement and depends more on the interaction between the DNA and its aqueous environment.


DNA melting

thermodynamic modeling

neuron scattering


Adrian Gonzalez Rodriguez

Universidad de Burgos

Institut Laue-Langevin

Chalmers, Fysik, Nano- och biofysik

Andrew R. Wildes

Institut Laue-Langevin

Estelle Mossou

Institut Laue-Langevin

Viviana Cristiglio

Institut Laue-Langevin

Gaël Moiroux

Centre national de la recherche scientifique (CNRS)

Université Grenoble Alpes

Jean Luc Garden

Centre national de la recherche scientifique (CNRS)

Université Grenoble Alpes

Santiago Cuesta-López

Universidad de Burgos

ICAMCyL Foundation

Nikos Theodorakopoulos

Theoretical and Physical Chemistry

Universität Konstanz

Michel Peyrard

Ecole Normale Superieure de Lyon


0006-3525 (ISSN) 1097-0282 (eISSN)

Vol. In Press


Fysikalisk kemi


Oceanografi, hydrologi, vattenresurser



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