Kinetic aspects of virus targeting by nanoparticles in vivo
Artikel i vetenskaplig tidskrift, 2021

One of the suggested ways of the use of nanoparticles in virology implies their association with and subsequent deactivation of virions. The conditions determining the efficiency of this approach in vivo are now not clear. Herein, I propose the first kinetic model describing the corresponding processes and clarifying these conditions. My analysis indicates that nanoparticles can decrease concentration of infected cells by a factor of one order of magnitude, but this decrease itself (without feedback of the immune system) is insufficient for full eradication of infection. It can, however, induce delay in the progress of infection, and this delay can help to form sufficient feedback of the immune system.

Inhibition

Nanoparticles

Association

Viral infection

Kinetic model

Författare

Vladimir Zhdanov

Russian Academy of Sciences

Chalmers, Fysik

Journal of Biological Physics

0092-0606 (ISSN) 1573-0689 (eISSN)

Vol. 47 95-101

Ämneskategorier

Immunologi

Annan kemiteknik

Mikrobiologi inom det medicinska området

DOI

10.1007/s10867-021-09570-z

PubMed

34080098

Mer information

Senast uppdaterat

2021-06-23