Time-Adaptive Determination of Drug Efficacy in Mathematical Model of HIV Infection
Artikel i vetenskaplig tidskrift, 2021

The paper considers a time-adaptive finite element method for determination of drug efficacy in a parameter identification problem (PIP) for a system of ordinary differential equations (ODE) that describes dynamics of the primary human immunodeficiency virus (HIV) infection with drug therapy. Tikhonov’s regularization method, optimization approach and finite element method to solve this problem are presented. A posteriori error estimates in the Tikhonov’s functional and reconstructed parameter are derived. Based on these estimates a time adaptive algorithm is formulated and numerically tested for different scenarios of noisy observations of virus population function. Numerical results show a significant improvement of reconstruction of drug efficacy parameter using the local time-adaptive mesh refinement method compared to the gradient method applied on a uniform time mesh.

Författare

Larisa Beilina

Chalmers, Matematiska vetenskaper, Tillämpad matematik och statistik

Göteborgs universitet

M. Eriksson

Göteborgs universitet

Irina Gainova

Siberian Branch of the RAS

Differential Equations and Dynamical Systems

0971-3514 (ISSN)

Vol. In Press

Ämneskategorier

Beräkningsmatematik

Reglerteknik

Signalbehandling

DOI

10.1007/s12591-021-00572-w

Mer information

Senast uppdaterat

2021-06-29