Defining the Scope of Exposome Studies and Research Needs from a Multidisciplinary Perspective
Reviewartikel, 2021

The concept of the exposome was introduced over 15 years ago to reflect the important role that the environment exerts on health and disease. While originally viewed as a call-to-arms to develop more comprehensive exposure assessment methods applicable at the individual level and throughout the life course, the scope of the exposome has now expanded to include the associated biological response. In order to explore these concepts, a workshop was hosted by the Gunma University Initiative for Advanced Research (GIAR, Japan) to discuss the scope of exposomics from an international and multidisciplinary perspective. This Global Perspective is a summary of the discussions with emphasis on (1) top-down, bottom-up, and functional approaches to exposomics, (2) the need for integration and standardization of LC- and GC-based high-resolution mass spectrometry methods for untargeted exposome analyses, (3) the design of an exposomics study, (4) the requirement for open science workflows including mass spectral libraries and public databases, (5) the necessity for large investments in mass spectrometry infrastructure in order to sequence the exposome, and (6) the role of the exposome in precision medicine and nutrition to create personalized environmental exposure profiles. Recommendations are made on key issues to encourage continued advancement and cooperation in exposomics.

Författare

Pei Zhang

Gunma University

China Pharmaceutical University

Karolinska Institutet

Christopher Carlsten

University of British Columbia (UBC)

Romanas Chaleckis

Gunma University

Karolinska Institutet

Kati Hanhineva

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Turun Yliopisto

Itä-Suomen Yliopisto

Mengna Huang

Brigham and Women's Hospital

Tomohiko Isobe

National Institute for Environmental Studies of Japan

Ville Mikael Koistinen

Turun Yliopisto

Itä-Suomen Yliopisto

Isabel Meister

Karolinska Institutet

Gunma University

Stefano Papazian

Stockholms universitet

Kalliroi Sdougkou

Stockholms universitet

Hongyu Xie

Stockholms universitet

Jonathan W. Martin

Stockholms universitet

Stephen M. Rappaport

University of California

Hiroshi Tsugawa

Tokyo University of Agriculture and Technology

Yokohama City University

RIKEN

Douglas I. Walker

Icahn School of Medicine at Mount Sinai

Tracey J. Woodruff

University of California

Robert O. Wright

Icahn School of Medicine at Mount Sinai

Craig E. Wheelock

Karolinska Institutet

Gunma University

Karolinska universitetssjukhuset

Environmental Science and Technology Letters

23288930 (eISSN)

Vol. In Press

Ämneskategorier

Etik

Tvärvetenskapliga studier

Övrig annan samhällsvetenskap

DOI

10.1021/acs.estlett.1c00648

Mer information

Senast uppdaterat

2021-10-06