Proof of concept for multiple nerve transfers to a single target muscle
Artikel i vetenskaplig tidskrift, 2021

Surgical nerve transfers are used to efficiently treat peripheral nerve injuries, neuromas, phantom limb pain, or improve bionic prosthetic control. Commonly, one donor nerve is transferred to one target muscle. However, the transfer of multiple nerves onto a single target muscle may increase the number of muscle signals for myoelectric prosthetic control and facilitate the treatment of multiple neuromas. Currently, no experimental models are available. This study describes a novel experimental model to investigate the neurophysiological effects of peripheral double nerve transfers to a common target muscle. In 62 male Sprague-Dawley rats, the ulnar nerve of the antebrachium alone (n=30) or together with the anterior interosseus nerve (n=32) was transferred to reinnervate the long head of the biceps brachii. Before neurotization, the motor branch to the biceps' long head was transected at the motor entry point. Twelve weeks after surgery, muscle response to neurotomy, behavioral testing, retrograde labeling, and structural analyses were performed to assess reinnervation. These analyses indicated that all nerves successfully reinnervated the target muscle. No aberrant reinnervation was observed by the originally innervating nerve. Our observations suggest a minimal burden for the animal with no signs of functional deficit in daily activities or auto-mutilation in both procedures. Furthermore, standard neurophysiological analyses for nerve and muscle regeneration were applicable. This newly developed nerve transfer model allows for the reliable and standardized investigation of neural and functional changes following the transfer of multiple donor nerves to one target muscle.

nerve transfer

targeted muscle reinnervation

peripheral nerve

nerve injury

rat model

prosthetic interfacing

Rat

motor unit

Författare

Matthias Luft

Medizinische Universität Wien

Johanna Klepetko

Medizinische Universität Wien

Silvia Muceli

Chalmers, Elektroteknik, Signalbehandling och medicinsk teknik, Medicinska signaler och system

Jaime Ibanez

University College London (UCL)

Imperial College London

Universidad de Zaragoza

Vlad Tereshenko

Medizinische Universität Wien

Christopher Festin

Medizinische Universität Wien

Gregor Laengle

Medizinische Universität Wien

Olga Politikou

Medizinische Universität Wien

Udo Maierhofer

Medizinische Universität Wien

Dario Farina

University College London (UCL)

Imperial College London

Oskar C. Aszmann

Medizinische Universität Wien

Konstantin Davide Bergmeister

Medizinische Universität Wien

Karl Landsteiner University of Health Sciences

eLife

2050-084X (ISSN)

Vol. 10 e71312

Ämneskategorier

Sjukgymnastik

Neurovetenskaper

Fysiologi

DOI

10.7554/eLife.71312

PubMed

34596042

Mer information

Senast uppdaterat

2021-11-17