Interactions Between Graphene-Based Materials and Biological Surfaces: A Review of Underlying Molecular Mechanisms
Reviewartikel, 2021

Understanding the underlying molecular mechanism of how graphene materials (GMs) interact with biological surfaces is the key to develop safe and effective biomedical applications of GMs. Here, a systematic and comprehensive mechanistic perspective of interactions between pristine GMs and biological membranes is provided. To this end, first the known mechanisms of interaction between GMs and membrane components are summarized and classified, with a focus on phospholipids, cholesterol, and membrane proteins. Both experimental observations and computational simulations are included. Detailed experimental conditions and physiochemical properties of GMs are listed for each cited application. At the end of this review, current challenges and conflicts that limit biomedical applications of GMs are discussed. Based on reported mechanisms, guidelines for future studies to address the remaining challenges are proposed, specifically with respect to modulating the intrinsic properties of GMs for more efficient and safer therapeutic applications.

cancer therapy

antibacterial activity

molecular mechanisms

graphene derivatives


biological membranes


Yanyan Chen

Chalmers, Biologi och bioteknik, Systembiologi

Santosh Pandit

Chalmers, Biologi och bioteknik, Systembiologi

Shadi Rahimi

Chalmers, Biologi och bioteknik, Systembiologi

Ivan Mijakovic

Danmarks Tekniske Universitet (DTU)

Chalmers, Biologi och bioteknik, Systembiologi


Advanced Materials Interfaces

2196-7350 (eISSN)

Vol. 8 24 2101132


Övrig annan teknik

Annan kemi




Mer information

Senast uppdaterat