Microbial genetic engineering approach to replace shark livering for squalene
Reviewartikel, 2022

Squalene is generally sourced from the liver oil of deep sea sharks (Squalus spp.), in which it accounts for 40–70% of liver mass. To meet the growing demand for squalene because of its beneficial effects for human health, three to six million deep sea sharks are slaughtered each year, profoundly endangering marine ecosystems. To overcome this unsustainable practice, microbial sources of squalene might offer a viable alternative to plant- or animal-based squalene, although only a few microorganisms have been found that are capable of synthesizing up to 30% squalene of dry biomass by native biosynthetic pathways. These squalene biosynthetic pathways, on the other hand, can be genetically manipulated to transform microorganisms into 'cellular factories' for squalene overproduction.

yeast

shark livering

squalene

genetic engineering

thraustochytrids

bacteria

Författare

Alok Patel

Luleå tekniska universitet

Maurizio Bettiga

Chalmers, Biologi och bioteknik, Industriell bioteknik

Bioeconomy Division

Ulrika Rova

Luleå tekniska universitet

P. Christakopoulos

Luleå tekniska universitet

Leonidas Matsakas

Luleå tekniska universitet

Trends in Biotechnology

0167-7799 (ISSN)

Vol. In Press

Ämneskategorier

Skogsvetenskap

Trädgårdsvetenskap/hortikultur

Miljövetenskap

DOI

10.1016/j.tibtech.2022.03.008

Mer information

Senast uppdaterat

2022-05-13