Diet- and microbiota-related metabolite, 5-aminovaleric acid betaine (5-AVAB), in health and disease
Reviewartikel, 2022

5-Aminovaleric acid betaine (5-AVAB) is a trimethylated compound associated with the gut microbiota, potentially produced endogenously, and related to the dietary intake of certain foods such as whole grains. 5-AVAB accumulates within the metabolically active tissues and has been typically found in higher concentrations in the heart, muscle, and brown adipose tissue. Furthermore, 5-AVAB has been associated with positive health effects such as fetal brain development, insulin secretion, and reduced cancer risk. However, it also has been linked with some negative health outcomes such as cardiovascular disease and fatty liver disease. At the cellular level, 5-AVAB can influence cellular energy metabolism by reducing β-oxidation of fatty acids. This review will focus on the metabolic role of 5-AVAB with respect to both physiology and pathology. Moreover, the analytics and origin of 5-AVAB and related compounds will be reviewed.

5-aminovaleric acid betaine (5-AVAB)

δ-valerobetaine (δVB)

N,N,N-trimethyl-5-aminovalerate (TMAV)

N,N,N-trimethyl-5-aminovaleric acid (TMAVA)

aminovaleric acid betaine

Författare

Retu Haikonen

Itä-Suomen Yliopisto

Olli Kärkkäinen

Itä-Suomen Yliopisto

Ville Mikael Koistinen

Itä-Suomen Yliopisto

Turun Yliopisto

Kati Hanhineva

Turun Yliopisto

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Itä-Suomen Yliopisto

Trends in Endocrinology and Metabolism

1043-2760 (ISSN) 1879-3061 (eISSN)

Vol. 33 7 463-480

Ämneskategorier

Annan klinisk medicin

Fysiologi

Näringslära

DOI

10.1016/j.tem.2022.04.004

PubMed

35508517

Mer information

Senast uppdaterat

2024-03-07