Dynamics of the normal gut microbiota: A longitudinal one-year population study in Sweden
Artikel i vetenskaplig tidskrift, 2022
Temporal dynamics of the gut microbiota potentially limit the identification of microbial features associated with health status. Here, we used whole-genome metagenomic and 16S rRNA gene sequencing to characterize the intra- and inter-individual variations of gut microbiota composition and functional potential of a disease-free Swedish population (n = 75) over one year. We found that 23% of the total compositional variance was explained by intra-individual variation. The degree of intra-individual compositional variability was negatively associated with the abundance of Faecalibacterium prausnitzii (a butyrate producer) and two Bifidobacterium species. By contrast, the abundance of facultative anaerobes and aerotolerant bacteria such as Escherichia coli and Lactobacillus acidophilus varied extensively, independent of compositional stability. The contribution of intra-individual variance to the total variance was greater for functional pathways than for microbial species. Thus, reliable quantification of microbial features requires repeated samples to address the issue of intra-individual variations of the gut microbiota.
gut microbiota
biomarker
healthy microbiota
stability
Proteobacteria
Enterobacteriaceae
Författare
Lisa M. Olsson
Wallenberg Lab.
Fredrik Boulund
Karolinska Institutet
Staffan Nilsson
Göteborgs universitet
Chalmers, Matematiska vetenskaper, Tillämpad matematik och statistik
Muhammad Tanweer Khan
Wallenberg Lab.
Anders Gummesson
Wallenberg Lab.
Sahlgrenska universitetssjukhuset
L. Fagerberg
Kungliga Tekniska Högskolan (KTH)
Lars Engstrand
Science for Life Laboratory (SciLifeLab)
Karolinska Institutet
Rosie Perkins
Wallenberg Lab.
Mathias Uhlen
Danmarks Tekniske Universitet (DTU)
Kungliga Tekniska Högskolan (KTH)
Göran Bergström
Sahlgrenska universitetssjukhuset
Wallenberg Lab.
Valentina Tremaroli
Wallenberg Lab.
Fredrik Bäckhed
Wallenberg Lab.
Sahlgrenska universitetssjukhuset
Köpenhamns universitet
Cell Host and Microbe
1931-3128 (ISSN) 19346069 (eISSN)
Vol. 30 5 726-739.e3Ämneskategorier
Mikrobiologi
DOI
10.1016/j.chom.2022.03.002
PubMed
35349787