Risk assessment with gut microbiome and metabolite markers in NAFLD development
Artikel i vetenskaplig tidskrift, 2022
A growing body of evidence suggests interplay between the gut microbiota and the pathogenesis of nonalcoholic fatty liver disease (NAFLD). However, the role of the gut microbiome in early detection of NAFLD is unclear. Prospective studies are necessary for identifying reliable, microbiome markers for early NAFLD. We evaluated 2487 individuals in a community-based cohort who were followed up 4.6 years after initial clinical examination and biospecimen sampling. Metagenomic and metabolomic characterizations using stool and serum samples taken at baseline were performed for 90 participants who progressed to NAFLD and 90 controls who remained NAFLD free at the follow-up visit. Cases and controls were matched for gender, age, body mass index (BMI) at baseline and follow-up, and 4-year BMI change. Machine learning models integrating baseline microbial signatures (14 features) correctly classified participants (auROCs of 0.72 to 0.80) based on their NAFLD status and liver fat accumulation at the 4-year follow up, outperforming other prognostic clinical models (auROCs of 0.58 to 0.60). We confirmed the biological relevance of the microbiome features by testing their diagnostic ability in four external NAFLD case-control cohorts examined by biopsy or magnetic resonance spectroscopy, from Asia, Europe, and the United States. Our findings raise the possibility of using gut microbiota for early clinical warning of NAFLD development.
Författare
Howell Leung
Hans-Knoll-Institute (HKI)
Xiaoxue Long
Shanghai Sixth People's Hospital
Yueqiong Ni
Hans-Knoll-Institute (HKI)
Shanghai Sixth People's Hospital
Lingling Qian
Shanghai Sixth People's Hospital
Emmanouil Nychas
Hans-Knoll-Institute (HKI)
Sara Leal Siliceo
Hans-Knoll-Institute (HKI)
Dennis Pohl
Danmarks Tekniske Universitet (DTU)
Kati Hanhineva
Itä-Suomen Yliopisto
Turun Yliopisto
Chalmers, Biologi och bioteknik, Livsmedelsvetenskap
Yan Liu
The University of Hong Kong
Aimin Xu
The University of Hong Kong
Henrik B. Nielsen
Danmarks Tekniske Universitet (DTU)
Eugeni Belda
Sorbonne Université
K. Clement
Sorbonne Université
Rohit Loomba
University of California
Huating Li
Shanghai Sixth People's Hospital
Weiping Jia
Shanghai Sixth People's Hospital
G. Panagiotou
The University of Hong Kong
Hans-Knoll-Institute (HKI)
Science Translational Medicine
1946-6234 (ISSN) 1946-6242 (eISSN)
Vol. 14 648 eabk0855-Ämneskategorier
Geriatrik
Klinisk laboratoriemedicin
Näringslära
DOI
10.1126/scitranslmed.abk0855
PubMed
35675435