Assembly of Aggregation-Induced Emission Active Bola-Amphiphilic Macromolecules into Luminescent Nanoparticles Optimized for Two-Photon Microscopy In Vivo
Artikel i vetenskaplig tidskrift, 2022
The (Z) and (E)-isomers of an extended tetraphenylethylene-based chromophore with optimized two-photon-induced luminescence properties are separated and functionalized with water-solubilizing pendant polymer groups, promoting their self-assembly in physiological media in the form of small, colloidal stable organic nanoparticles. The two resulting fluorescent suspensions are then evaluated as potential two-photon luminescent contrast agents for intravital epifluorescence and two-photon fluorescence microscopy. Comparisons with previously reported works involving similar fluorophores devoid of polymer side chains illustrate the benefits of later functionalization regarding the control of the self-assembly of the nano-objects and ultimately their biocompatibility toward the imaged organism.
Författare
Jean Rouillon
Université de Lyon
Centre national de la recherche scientifique (CNRS)
Lamiaa M. A. Ali
Alexandria University
Université de Montpellier
Kamel Hadj-Kaddour
Université de Montpellier
Raphael Marie-Luce
Université de Lyon
Guillaume Simon
Université de Lyon
Melanie Onofre
Université de Montpellier
Sandrine Denis Quanquin
Université de Lyon
Marion Jean
Aix-Marseille Université
Muriel Albalat
Aix-Marseille Université
Nicolas Vanthuyne
Aix-Marseille Université
Guillaume Micouin
Université de Lyon
Akos Banyasz
Université de Lyon
Magali Gary-Bobo
Université de Montpellier
Cyrille Monnereau
Université de Lyon
Chantal Andraud
Université de Lyon
Biomacromolecules
1525-7797 (ISSN) 1526-4602 (eISSN)
Vol. 23 6 2485-2495Ämneskategorier (SSIF 2011)
Fysikalisk kemi
Biokemi och molekylärbiologi
DOI
10.1021/acs.biomac.2c00232
PubMed
35608946