Assembly of Aggregation-Induced Emission Active Bola-Amphiphilic Macromolecules into Luminescent Nanoparticles Optimized for Two-Photon Microscopy In Vivo
Artikel i vetenskaplig tidskrift, 2022
The (Z) and (E)-isomers of an extended tetraphenylethylene-based chromophore with optimized two-photon-induced luminescence properties are separated and functionalized with water-solubilizing pendant polymer groups, promoting their self-assembly in physiological media in the form of small, colloidal stable organic nanoparticles. The two resulting fluorescent suspensions are then evaluated as potential two-photon luminescent contrast agents for intravital epifluorescence and two-photon fluorescence microscopy. Comparisons with previously reported works involving similar fluorophores devoid of polymer side chains illustrate the benefits of later functionalization regarding the control of the self-assembly of the nano-objects and ultimately their biocompatibility toward the imaged organism.
Författare
Jean Rouillon
Chalmers, Kemi och kemiteknik, Kemi och biokemi
Lamiaa M. A. Ali
Université de Montpellier
Alexandria University
Kamel Hadj-Kaddour
Université de Montpellier
Raphael Marie-Luce
Université de Lyon
Guillaume Simon
Université de Lyon
Melanie Onofre
Université de Montpellier
Sandrine Denis Quanquin
Université de Lyon
Marion Jean
Aix-Marseille Université
Muriel Albalat
Aix-Marseille Université
Nicolas Vanthuyne
Aix-Marseille Université
Guillaume Micouin
Université de Lyon
Akos Banyasz
Université de Lyon
Magali Gary-Bobo
Université de Montpellier
Cyrille Monnereau
Université de Lyon
Chantal Andraud
Université de Lyon
Biomacromolecules
1525-7797 (ISSN) 1526-4602 (eISSN)
Vol. 23 6 2485-2495Ämneskategorier
Fysikalisk kemi
Biokemi och molekylärbiologi
DOI
10.1021/acs.biomac.2c00232
PubMed
35608946