Extracellular interplay of amyloid fibrils and neural cells
Artikel i vetenskaplig tidskrift, 2023

Some neurological disorders such e.g. as Alzheimer disease are accompanied by the appearance of amyloid fibrils inside and outside cells. Herein, I present a generic coarse-grained kinetic mean-field model describing at the extracellular level the interplay of fibrils and cells. It includes the formation and degradation of fibrils, activation of healthy cells with respect to the fabrication of fibrils, and death of activated cells. The corresponding analysis indicates that the disease development can occur in two qualitatively different regimes. The first one is controlled primarily by the intrinsic factors resulting in slow increase of fibril production inside cells. The second one implies faster self-promoted growth of the fibril population by analogy with explosion. This prediction reported as a hypothesis is of interest for conceptual understanding of the neurological disorders.

Neurology

Amyloid fibrils

Alzheimer disease

Kinetic regimes

Plagued cells

Kinetic model

Författare

Vladimir Zhdanov

Chalmers, Fysik

Russian Academy of Sciences

BioSystems

0303-2647 (ISSN) 18728324 (eISSN)

Vol. 231 104971

Ämneskategorier

Neurovetenskaper

Cell- och molekylärbiologi

DOI

10.1016/j.biosystems.2023.104971

PubMed

37429375

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Senast uppdaterat

2023-09-14