Microbial robustness in bioprocesses
Poster (konferens), 2023

Yeast is broadly exploited for industrial use, and strains are constantly improved to meet the requirements to produce the targeted product with high yield, productivity and titer. Successful strains have consistent performance also in presence of different perturbations, i.e. their performance is robust. The concept of microbial robustness will be discussed and contrasted to tolerance toward specific stresses. Furthermore, a method to quantitatively assess microbial robustness will be presented. This method allows a high throughput evaluation, in a perturbation space where different cellular function can form the basis for the evaluation. Another important tool box to examine intracellular status in face of pertubations are biosensors. Examples of applying these two methodologies towards microbial robustness will be discussed. We have used the tools to scale down bioprocesses and their perturbation, to follow adaptive laboratory evolution and to gain understanding of subpopulations.

bioproduction

robustness

Författare

Lisbeth Olsson

Chalmers, Life sciences, Industriell bioteknik

Luca Torello Pianale

Chalmers, Life sciences, Industriell bioteknik

Cecilia Trivellin

Chalmers, Life sciences, Industriell bioteknik

Nathália Vilela

Chalmers, Life sciences, Industriell bioteknik

PYFF8 - 8th Conference on Physiology of Yeasts and Filamentous Fungi
Cork, Ireland,

Microbial robustness - a key for sustainable and efficient biotechnology-based production

Novo Nordisk Fonden (NNF19OC00550444), 2019-09-01 -- 2024-08-31.

Ämneskategorier

Industriell bioteknik

Bioprocessteknik

Mikrobiologi

Annan industriell bioteknik

Mer information

Senast uppdaterat

2024-07-05