Dynamic Release from Acetalated Dextran Nanoparticles for Precision Therapy of Inflammation
Artikel i vetenskaplig tidskrift, 2024

Polymer-based nanoparticles (NPs) that react to altered physiological characteristics have the potential to enhance the delivery of therapeutics to a specific area. These materials can utilize biochemical triggers, such as low pH, which is prone to happen locally in an inflammatory microenvironment due to increased cellular activity. This reduced pH is neutralized when inflammation subsides. For precise delivery of therapeutics to match this dynamic reaction, drug delivery systems (DDS) need to not only release the drug (ON) but also stop the release (OFF) autonomously. In this study, we use a systematic approach to optimize the composition of acetalated dextran (AcDex) NPs to start (ON) and stop (OFF) releasing model cargo, depending on local pH changes. By mixing ratios of AcDex polymers (mixed NPs), we achieved a highly sensitive material that was able to rapidly release cargo when going from pH 7.4 to pH 6.0. At the same time, the mix also offered a stable composition that enabled a rapid ON/OFF/ON/OFF switching within this narrow pH range in only 90 min. These mixed NPs were also sensitive to biological pH changes, with increased release in the presence of inflammatory cells compared to healthy cells. Such precise and controllable characteristics of a DDS position mixed NPs as a potential treatment platform to inhibit disease flare-ups, reducing both systemic and local side effects to offer a superior treatment option for inflammation compared to conventional systems.


Gizem Erensoy

Chalmers, Life sciences, Kemisk biologi

Loise Råberg

Chalmers, Life sciences, Kemisk biologi

Ula von Mentzer

Chalmers, Life sciences, Kemisk biologi

Luca Dirk Menges

Sahlgrenska universitetssjukhuset

Endri Bardhi

Student vid Chalmers

A. K. Hultgård Ekwall

Sahlgrenska universitetssjukhuset

Göteborgs universitet

Alexandra Stubelius

Chalmers, Life sciences, Kemisk biologi

ACS Applied Bio Materials

25766422 (eISSN)

Vol. 7


Medicinsk bioteknologi


Chalmers materialanalyslaboratorium



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