Lifetime Duration of Breastfeeding and Cardiovascular Risk in Women With Type 2 Diabetes or a History of Gestational Diabetes: Findings From Two Large Prospective Cohorts
Artikel i vetenskaplig tidskrift, 2024

OBJECTIVE: Breastfeeding duration is inversely associated with risks of cardiovascular disease (CVD) and type 2 diabetes in parous women. However, the association among women at high risk, including women with type 2 diabetes or gestational diabetes mellitus (GDM) is unclear.
RESEARCH DESIGN AND METHODS: We included 15,146 parous women with type 2 diabetes from the Nurses' Health Study I and II (NHS, NHS II) and 4,537 women with a history of GDM from NHS II. Participants reported history of breastfeeding via follow-up questionnaires. Incident CVD by 2017 comprised stroke or coronary heart disease (CHD) (myocardial infarction, coronary revascularization). Adjusted hazard ratios (aHRs) and 95% CIs were estimated using Cox models.
RESULTS: We documented 1,159 incident CVD cases among women with type 2 diabetes in both cohorts during 188,874 person-years of follow-up and 132 incident CVD cases among women with a GDM history during 100,218 person-years of follow-up. Longer lifetime duration of breastfeeding was significantly associated with lower CVD risk among women with type 2 diabetes, with pooled aHR of 0.68 (95% CI 0.54-0.85) for >18 months versus 0 months and 0.94 (0.91-0.98) per 6-month increment in breastfeeding. Similar associations were observed with CHD (pooled aHR 0.93 [0.88-0.97]) but not with stroke (0.96 [0.91-1.02]) per 6-month increment in breastfeeding. Among women with GDM history, >18 months versus 0 months of breastfeeding was associated with an aHR of 0.49 (0.28-0.86) for total CVD.
CONCLUSIONS: Longer duration of breastfeeding was associated with lower risk of CVD in women with type 2 diabetes or GDM.

Författare

Anna Birukov

Harvard School of Public Health

Deutsches Institut für Ernährungsforschung

Marta Guasch-Ferré

Novo Nordisk Fonden

Harvard School of Public Health

Sylvia H. Ley

Tulane University

Deirdre K. Tobias

Brigham and Women's Hospital

Harvard School of Public Health

Fenglei Wang

Harvard School of Public Health

Clemens Wittenbecher

Harvard School of Public Health

Chalmers, Life sciences, Livsmedelsvetenskap

Jiaxi Yang

Yong Loo Lin School of Medicine

Jo Ann E. Manson

Harvard School of Public Health

Brigham and Women's Hospital

Jorge E. Chavarro

Brigham and Women's Hospital

Harvard School of Public Health

Frank B. Hu

Harvard School of Public Health

Brigham and Women's Hospital

Cuilin Zhang

Harvard School of Public Health

Yong Loo Lin School of Medicine

Diabetes care

19355548 (eISSN)

Vol. 47 4 720-728

Ämneskategorier

Endokrinologi och diabetes

Kardiologi

DOI

10.2337/dc23-1494

PubMed

38377484

Mer information

Senast uppdaterat

2024-08-08