Extended reality used in the treatment of phantom limb pain: a multicenter, double-blind, randomized controlled trial
Artikel i vetenskaplig tidskrift, 2025
Phantom limb pain (PLP) represents a significant challenge after amputation. This study investigated the use of phantom motor execution (PME) and phantom motor imagery (PMI) facilitated by extended reality (XR) for the treatment of PLP. Both treatments used XR, but PME involved overt execution of phantom movements, relying on the decoding of motor intent using machine learning to enable real-time control in XR. In contrast, PMI involved mental rehearsal of phantom movements guided by XR. The study hypothesized that PME would be superior to PMI. A multicenter, double-blind, randomized controlled trial was conducted in 9 outpatient clinics across 7 countries. Eighty-one participants with PLP were randomly assigned to PME or PMI training. The primary outcome was the change in PLP, measured by the Pain Rating Index, from baseline to treatment cessation. Secondary outcomes included various aspects related to PLP, such as the rate of clinically meaningful reduction in pain (CMRP;.50% pain decrease). No evidence was found for superiority of overt execution (PME) over imagery (PMI) using XR. PLP decreased by 64.5% and 68.2% in PME and PMI groups, respectively. Thirty-seven PME participants (71%) and 19 PMI participants (68%) experienced CMRP. Positive changes were recorded in all other outcomes, without group differences. Pain reduction for PME was larger than previously reported. Despite our initial hypothesis not being confirmed, PME and PMI, aided by XR, are likely to offer meaningful PLP relief to most patients. These findings merit consideration of these therapies as viable treatment options and alternatives to pharmacological treatments.
Pain
Pain management
Amputation
Virtual reality exposure therapy
Augmented reality
Phantom limb
Rehabilitation
Författare
Eva Lendaro
Chalmers, Elektroteknik
McGovern Institute
Corry K. Van Der Sluis
Rijksuniversiteit Groningen
Liselotte Hermansson
Faculty of Medicine and Health
Lina Bunketorp-Käll
Sahlgrenska universitetssjukhuset
Göteborgs universitet
H. Burger
Institute for Rehabilitation Ljubljana
Univerza V Ljubljani
Els Keesom
Rijksuniversiteit Groningen
C. Widehammar
Faculty of Medicine and Health
Maria Munoz-Novoa
Integrum AB
Center for Bionics and Pain Research
Brian E. McGuire
National University of Ireland
Paul O. Reilly
National University of Ireland
Eric Earley
Chalmers, Elektroteknik, System- och reglerteknik
University of Colorado
Center for Bionics and Pain Research
Colorado School of Public Health
Sonam Iqbal
Center for Bionics and Pain Research
Integrum AB
Morten B. Kristoffersen
Rijksuniversiteit Groningen
Center for Bionics and Pain Research
Göteborgs universitet
A. Stockselius
Bräcke diakoni
Lena Gudmundson
Bräcke diakoni
Wendy Hill
Institute of Biomedical Engineering
Martin Diers
Ruhr-Universität Bochum
Kristi L. Turner
Center for Bionic Medicine
Thomas Weiss
Friedrich-Schiller-Universität Jena
Max Jair Ortiz Catalan
Chalmers, Elektroteknik, System- och reglerteknik
Center for Bionics and Pain Research
University of Melbourne
Bionics Institute
Pain
0304-3959 (ISSN) 18726623 (eISSN)
Vol. 166 3 571-586Neuromuskulär styrning av robotben
VINNOVA (2018-03235), 2018-11-26 -- 2020-10-31.
Ämneskategorier (SSIF 2011)
Sjukgymnastik
Allmänmedicin
Tillämpad psykologi
DOI
10.1097/j.pain.0000000000003384
PubMed
39250328