Evaluation of [18F]PSMA-1007 uptake variability in patients with prostate cancer
Artikel i vetenskaplig tidskrift, 2025

Background: The biodistribution of PSMA-ligands is of interest in radionuclide therapy planning. We investigated the variability of [18F]PSMA-1007 uptake in organs at risk and in relation to tumour burden in prostate cancer patients. Methods: A total of 1086 patients who underwent PSMA PET-CT for staging or recurrence of prostate cancer were included. Total lesion volume (TLV) and total lesion uptake (TLU) were calculated from manual segmentations. The mean standardized uptake value (SUVmean) in the organs at risk kidneys, liver, parotid glands and spleen was obtained. Correlations between TLV/TLU and SUVmean in normal tissues were calculated using Spearman rank correlation. SUVmean in normal tissues was stratified into groups based on TLV. Results: The median (IQR) SUVmean of the kidneys, liver, parotid glands, and spleen was 13.1 (IQR 4.6), 11.8 (4.4), 18.6 (6.8) and 11.3 (5.8), respectively. The median TLV was 3.8 cm3 (9.7) and median TLU was 31.2 cm3 (106.3). There was no significant correlation between TLV or TLU and SUVmean for the liver, parotid glands, or spleen, but a weak negative correlation between TLV/TLU and SUVmean in the kidneys (r = −0.011, p = 0.0005; r = −0.09, p = 0.003). There was a tendency towards a lower SUVmean in the kidneys and parotid glands in patients with a very high TLV. Conclusions: There was a large uptake variability in organs at risk, which demonstrates the need for individual pretherapy dosimetry. There may be a tumour sink effect in the kidneys and parotid glands in patients with a very high TLV.

PET, tumour sink effect

prostate cancer

radioligand therapy

PSMA

[18F]PSMA−1007

Författare

E. Tragardh

Skånes universitetssjukhus (SUS)

Lunds universitet

Måns Larsson

Eigenvision AB

David Minarik

Lunds universitet

Skånes universitetssjukhus (SUS)

Olof Enqvist

Chalmers, Elektroteknik, Signalbehandling och medicinsk teknik

Eigenvision AB

L. Edenbrandt

Göteborgs universitet

Clinical Physiology and Functional Imaging

1475-0961 (ISSN) 1475097x (eISSN)

Vol. 45 4 e70016

Drivkrafter

Hållbar utveckling

Styrkeområden

Hälsa och teknik

Ämneskategorier (SSIF 2025)

Radiologi och bildbehandling

DOI

10.1111/cpf.70016

Mer information

Senast uppdaterat

2025-06-26