Noninvasive cardiac modulation via triplet-sensitized photoswitching in the phototherapeutic window
Artikel i vetenskaplig tidskrift, 2025
Red, far red, or near-infrared photoswitchable drugs offer immense photo-pharmacological advantages due to the higher light penetration through the skin. Such photoactivation is achieved using processes such as two- and three-photon absorption, excited-state absorption, and triplet-triplet annihilation upconversion, which require higher photon fluences (W to kW cm−2) than the resilience constraints of skin (200 mW cm−2). Herein, a generalized approach of cis-to-trans photoisomerization of azobenzenes is demonstrated via triplet sensitization with NIR-I illumination (850 nm) of a new Zn-octa-substituted phthalocyanine photosensitizer, in aqueous medium at 2.62 mW cm−2. The approach is applied to control the heart rate of a frog tadpole via cis-to-trans photoisomerization of an azobenzene-functionalized muscarinic acetylcholine receptor M2 agonist in the phototherapeutic window (730 nm excitation: 42 mW cm−2). This advance highlights a powerful photo-pharmacological strategy for modulation of in vivo activity at 2-4 orders of magnitude lower photon fluences of NIR light compared to established methods.
Författare
Lukas Naimovičius
Vilniaus universitetas
Consejo Superior de Investigaciones Científicas (CSIC)
Mila Miroshnichenko
Consejo Superior de Investigaciones Científicas (CSIC)
Ekin Opar
Universitat de Barcelona
CIBER Bioingenieria, Biomateriales y Nanomedicina
Instituto de Bioingeniería de Cataluña
Helen Hölzel
Universitat Politecnica de Catalunya
Masa Aki Morikawa
Kyushu University
Nobuo Kimizuka
Kyushu University
Manvydas Dapkevičius
Vilniaus universitetas
Justas Lekavičius
Vilniaus universitetas
Edvinas Radiunas
Vilniaus universitetas
Karolis Kazlauskas
Vilniaus universitetas
Víctor Cilleros-Mañé
CIBER Bioingenieria, Biomateriales y Nanomedicina
Instituto de Bioingeniería de Cataluña
Fabio Riefolo
CIBER Bioingenieria, Biomateriales y Nanomedicina
Instituto de Bioingeniería de Cataluña
Carlo Matera
CIBER Bioingenieria, Biomateriales y Nanomedicina
Universita' degli Studi di Milano
Instituto de Bioingeniería de Cataluña
Kevser Harmandar
Acibadem Universitesi
Masahiko Taniguchi
North Carolina State University
Fabienne Dumoulin
Acibadem Universitesi
Jonathan S. Lindsey
North Carolina State University
Pankaj Bharmoria
Consejo Superior de Investigaciones Científicas (CSIC)
Pau Gorostiza
CIBER Bioingenieria, Biomateriales y Nanomedicina
Instituto de Bioingeniería de Cataluña
Institucio Catalana de Recerca i Estudis Avancats
Kasper Moth-Poulsen
Universitat Politecnica de Catalunya
Chalmers, Kemi och kemiteknik, Tillämpad kemi
Consejo Superior de Investigaciones Científicas (CSIC)
Institucio Catalana de Recerca i Estudis Avancats
Nature Communications
2041-1723 (ISSN) 20411723 (eISSN)
Vol. 16 1 6377Molecular Solar Thermal energy storage systems (MOST)
Energimyndigheten (2019-010724), 2019-05-07 -- 2019-09-03.
Europeiska kommissionen (EU) (EC/H2020/951801), 2020-09-01 -- 2024-02-29.
Photo Thermal Management Materials (PHOTERM)
Europeiska kommissionen (EU) (EC/H2020/101002131), 2021-10-01 -- 2026-09-30.
Ämneskategorier (SSIF 2025)
Läkemedelskemi
DOI
10.1038/s41467-025-61301-3
PubMed
40640135