Oral Extended-Release Formulations

Kapitel i bok, 2010

In order to achieve therapeutic effect, a drug needs to reach the right place in the body at the right time. For some drugs, this may be achieved by simple solutions or solid dosage forms with an instant drug release while, for others, one has to modify the drug release, such as modified-release (MR) formulations and oral extended-release (ER) formulations. This article focuses on formulation principles and manufacturing of the different forms of ER formulations, such as insoluble matrix tablets, membrane-coated oral extended release, and hydrophilic matrix tablets.