IgG N-Glycosylation and Incident Neuropathy and Nephropathy in People With Type 2 Diabetes: A Pooled Analysis of Prospective Cohort Studies
Artikel i vetenskaplig tidskrift, 2026
OBJECTIVE: To examine whether IgG N-glycosylation patterns are prospectively associated with incident diabetic nephropathy and neuropathy. RESEARCH DESIGN AND METHODS: We analyzed IgG N-glycosylation profiles in four cohorts: EPIC-Potsdam, DiaGene, GenoDiabMar, and Hoorn DCS. Among 3,263 individuals with and without type 2 diabetes at profiling, 674 incident neuropathy and 639 incident nephropathy cases occurred after diabetes diagnosis. Associations of IgG N-glycan peaks (IgG-GPs) and traits with incident outcomes were examined using Cox models and meta-analyzed across cohorts. RESULTS: Agalactosylated, asialylated, and bisected IgG-GPs were associated with higher nephropathy risk (IgG-GP3: hazard ratio [HR] 1.13 [95% CI 1.04-1.24]; IgG-GP4: HR 1.15 [95% CI 1.05-1.26]), while galactosylated and sialylated IgG-GPs were associated with lower risk (IgG-GP14: HR 0.86 [95% CI 0.78-0.94]; IgG-GP18: HR 0.85 [95% CI 0.77-0.94]) (all false discovery rate <0.05). Associations of IgG-GPs with incident neuropathy were rendered nonsignificant after multiple testing correction. CONCLUSIONS: IgG N-glycosylation may reflect immune-related mechanisms relevant to diabetic nephropathy; but the evidence between IgG-GPs and diabetic neuropathy remains inconclusive.
Författare
Cecilia Martinez Escobedo
Chalmers, Life sciences, Livsmedelsvetenskap
Anna Birukov
Harvard School of Public Health
Deutsches Institut für Ernährungsforschung
Ralph Heijmans
Erasmus Universiteit Rotterdam
Olga Kuxhaus
Deutsches Institut für Ernährungsforschung
Deutsches Zentrum für Diabetesforschung (DZD)
Fabian Eichelmann
Deutsches Zentrum für Diabetesforschung (DZD)
Deutsches Institut für Ernährungsforschung
Roderick C. Slieker
Universiteit Leiden
Universiteit Van Amsterdam
Elham Memarian
Universiteit Leiden
Nina Simunic-Briski
Genos
Femke Rutters
Universiteit Van Amsterdam
Marieke T. Blom
Amsterdam Public Health Research Institute
Universiteit Van Amsterdam
Marta Riera
Hospital del Mar Medical Research Institute
Marta Crespo
Hospital del Mar Medical Research Institute
Manfred Wuhrer
Universiteit Leiden
Clara Barrios
Hospital del Mar Medical Research Institute
Mandy van Hoek
Erasmus Universiteit Rotterdam
Leen M. 't Hart
Universiteit Leiden
Universiteit Van Amsterdam
Eric Sijbrands
Erasmus Universiteit Rotterdam
Gordan Lauc
Sveučilište u Zagrebu
Genos
Matthias B. Schulze
Universität Potsdam
Deutsches Zentrum für Diabetesforschung (DZD)
Deutsches Institut für Ernährungsforschung
Clemens Wittenbecher
Chalmers, Life sciences, Livsmedelsvetenskap
Diabetes Care
0149-5992 (ISSN) 19355548 (eISSN)
Vol. 49 9 1714-1719Ämneskategorier (SSIF 2025)
Endokrinologi och diabetes
DOI
10.2337/dc26-0620
PubMed
42467059