Dihydrotestosterone treatment results in obesity and altered lipid metabolism in orchidectomized mice.
Artikel i vetenskaplig tidskrift, 2006

OBJECTIVE: To determine the role of androgen receptor (AR) activation for adipose tissue metabolism. Sex steroids are important regulators of adipose tissue metabolism in men. Androgens may regulate the adipose tissue metabolism in men either directly by stimulation of the AR or indirectly by aromatization of androgens into estrogens and, thereafter, by stimulation of the estrogen receptors. Previous studies have shown that estrogen receptor alpha stimulation results in reduced fat mass in men. RESEARCH METHODS AND PROCEDURES: Orchidectomized mice were treated with the non-aromatizable androgen 5alpha-dihydrotestosterone (DHT), 17beta-estradiol, or vehicle. Vo(2), Vco(2), resting metabolic rate, locomotor activity, and food consumption were measured. Furthermore, changes in hepatic gene expression were analyzed. RESULTS: DHT treatment resulted in obesity, associated with reduced energy expenditure and fat oxidation. In contrast, DHT did not affect food consumption or locomotor activity. Furthermore, DHT treatment resulted in increased high-density lipoprotein-cholesterol and triglyceride levels associated with markedly decreased 7alpha-hydroxylase gene expression, indicating decreased bile acid production. DISCUSSION: We showed that AR activation results in obesity and altered lipid metabolism in orchidectomized mice. One may speculate that AR antagonists might be useful in the treatment of obesity in men.

blood

physiology

Indirect

drug effects

Mice

Androgen

Mice

Triglycerides

Receptors

Mice

Cholesterol

pharmacology

Knockout

adverse effects

Liver

metabolism

Male

drug effects

drug effects

Animals

Body Weight

blood

Calorimetry

blood

Cholesterol

drug effects

Gene Expression Regulation

Estrogen Receptor alpha

metabolism

metabolism

Dihydrotestosterone

Lipid Metabolism

metabolism

genetics

Adiposity

Orchiectomy

Obesity

chemically induced

drug effects

HDL

Inbred C57BL

Författare

Sofia Movérare-Skrtic

Göteborgs universitet

Katrien Venken

Niklas Andersson

Göteborgs universitet

Marie K Lindberg

Göteborgs universitet

Johan Svensson

Göteborgs universitet

Charlotte Swanson

Göteborgs universitet

Dirk Vanderschueren

Jan Oscarsson

Göteborgs universitet

Jan-Ake Gustafsson

Claes Ohlsson

Göteborgs universitet

Obesity

1930-7381 (ISSN)

Vol. 14 662-72

Ämneskategorier

Endokrinologi och diabetes

Fysiologi

Kardiologi

DOI

10.1038/oby.2006.75

PubMed

16741268