Charged microcapsules for controlled release of hydrophobic actives Part II: Surface modification by LbL adsorption and lipid bilayer formation on properly anchored dispersant layers
Artikel i vetenskaplig tidskrift, 2013

Charge microcapsules with a dodecane core and a poly(methyl methacrylate) (PMMA) shell have been prepared via the internal phase separation method using ionic dispersants. The microcapsules have subsequently been surface modified with polyelectrolyte multilayers and lipid bilayers. Two types of ionic dispersant systems have been investigated: a small set of ionic amphiphilic block copolymers of poly(methyl methacrylate)-block-poly(sodium (meth)acrylate) type and an oil-soluble anionic surfactant, sodium 1,5-dioxo-1,5-bis(3,5,5-trimethylhexyloxy)-3((3,5,5trimethylhexyloxy)car bonyl)pentane-2-sulfonate, in combination with a water-soluble polycation, poly(diallyldimethylammonium chloride). The Layer-by-Layer adsorption of the polyelectrolyte pair poly(diallydimethylammonium chloride) (350,000 g/mol) and poly(sodium methacrylate) (15,000 g/mol) was successfully made on both microcapsule systems with the formation of very thin multilayers as indicated with quartz crystal microbalance with dissipation monitoring (QCM-D) measurements on model surfaces. Formation of a lipid bilayer on the surface of the microcapsules from liposomes with a charge opposite that of the capsule surface was also proven to be successful as indicated by the C-potential of the microcapsules, the characteristic frequency shift as measured with QCM-D and fluorescence recovery after photobleaching (FRAP) on model systems. However, the proper anchorage of the dispersants in the underlying PMMA surface was key for the successful surface modification.


electrostatic interactions


Lipid vesicle

vesicle adsorption

Quartz crystal microbalance with dissipation monitoring

shell microcapsules

Core-shell particle

emulsion droplets

colloidal particles

internal phase-separation



polyelectrolyte multilayer capsules


Markus Andersson Trojer

SuMo Biomaterials

Chalmers, Kemi- och bioteknik, Teknisk ytkemi

Ye Li

Chalmers, Kemi- och bioteknik, Teknisk ytkemi

Maria Wallin

Chalmers, Kemi- och bioteknik, Teknisk ytkemi

Krister Holmberg

Chalmers, Kemi- och bioteknik, Teknisk ytkemi

Magnus Nydén

SuMo Biomaterials

Chalmers, Kemi- och bioteknik, Teknisk ytkemi

Journal of Colloid and Interface Science

0021-9797 (ISSN) 1095-7103 (eISSN)

Vol. 409 8-17


Fysikalisk kemi





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