Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study.
Artikel i vetenskaplig tidskrift, 2017

Wide-scale profiling technologies including metabolomics broaden the possibility of novel discoveries related to the pathogenesis of type 2 diabetes (T2D). By applying non-targeted metabolomics approach, we investigated here whether serum metabolite profile predicts T2D in a well-characterized study population with impaired glucose tolerance by examining two groups of individuals who took part in the Finnish Diabetes Prevention Study (DPS); those who either early developed T2D (n = 96) or did not convert to T2D within the 15-year follow-up (n = 104). Several novel metabolites were associated with lower likelihood of developing T2D, including indole and lipid related metabolites. Higher indolepropionic acid was associated with reduced likelihood of T2D in the DPS. Interestingly, in those who remained free of T2D, indolepropionic acid and various lipid species were associated with better insulin secretion and sensitivity, respectively. Furthermore, these metabolites were negatively correlated with low-grade inflammation. We replicated the association between indolepropionic acid and T2D risk in one Finnish and one Swedish population. We suggest that indolepropionic acid, a gut microbiota-produced metabolite, is a potential biomarker for the development of T2D that may mediate its protective effect by preservation of β-cell function. Novel lipid metabolites associated with T2D may exert their effects partly through enhancing insulin sensitivity.

Författare

Vanessa D de Mello

Itä-Suomen Yliopisto

Jussi Paananen

Itä-Suomen Yliopisto

Jaana Lindström

National Institute for Health and Welfare

Maria A Lankinen

Itä-Suomen Yliopisto

Lin Shi

Sveriges lantbruksuniversitet (SLU)

Johanna Kuusisto

Itä-Suomen Yliopisto

Jussi Pihlajamäki

Kuopio University Hospital

Itä-Suomen Yliopisto

Seppo Auriola

Itä-Suomen Yliopisto

Marko Lehtonen

Itä-Suomen Yliopisto

Olov Rolandsson

Umeå universitet

Ingvar A Bergdahl

Umeå universitet

Elise Nordin

Sveriges lantbruksuniversitet (SLU)

Pirjo Ilanne-Parikka

Tampere University Hospital

Diabetes Centre Finnish Diabetes Association

Sirkka Keinänen-Kiukaanniemi

University of Oulu

Oulu University Hospital

Rikard Landberg

Sveriges lantbruksuniversitet (SLU)

Karolinska Institutet

Johan G Eriksson

Vasa centralsjukhus

National Institute for Health and Welfare

Helsingfors universitet

Helsinki University Central Hospital

Jaakko Tuomilehto

Danube Univ

National Institute for Health and Welfare

King Abdulaziz University

Kati Hanhineva

Itä-Suomen Yliopisto

Matti Uusitupa

Itä-Suomen Yliopisto

Kuopio University Hospital

Scientific Reports

2045-2322 (ISSN)

Vol. 7 46337-

Styrkeområden

Livsvetenskaper och teknik (2010-2018)

Ämneskategorier

Näringslära

DOI

10.1038/srep46337

PubMed

28397877

Mer information

Senast uppdaterat

2019-06-05