Pulling-induced rupture of ligand-receptor bonds between a spherically shaped bionanoparticle and the support
Artikel i vetenskaplig tidskrift, 2018

Contacts of biological or biologically-inspired spherically shaped nanoparticles (e.g., virions or lipid nanoparticles used for intracellular RNA delivery) with a lipid membrane of cells are often mediated by multiple relatively weak ligand-receptor bonds. Such contacts can be studied at a supported lipid bilayer. The rupture of bonds can be scrutinized by using force spectroscopy. Bearing a supported lipid bilayer in mind, the author shows analytically that the corresponding dependence of the force on the nanoparticle displacement and the effect of the force on the bond-rupture activation energy are qualitatively different compared to what is predicted by the conventional Bell approximation.

Force spectroscopy

Spherical nanoparticles


Bond rupture


Vladimir Zhdanov

Russian Academy of Sciences

Chalmers, Fysik, Kemisk fysik

Physics Letters, Section A: General, Atomic and Solid State Physics

0375-9601 (ISSN)

Vol. 382 15 1052-1057


Biokemi och molekylärbiologi

Bioteknisk apparatteknik




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