Photothermal DNA Release from Laser-Tweezed Individual Gold Nanomotors Driven by Photon Angular Momentum
Artikel i vetenskaplig tidskrift, 2018

Gold nanoparticles offer a unique possibility for contact-free bioanalysis and actuation with high spatial resolution that increases their potential for bioapplications such as affinity-based biosensing, drug delivery, and cancer treatment. Here we demonstrate an ultrasensitive optomechanical method for probing and releasing DNA cargo from individual gold nanoparticles trapped and manipulated by laser tweezers. Single nanorods are operated as rotational nanomotors, driven and controlled by circularly polarized laser light in aqueous solution. By rotational dynamics analysis, we resolve differences in the thickness of adsorbed ultrathin molecular layers, including different DNA conformations, with nanometer resolution. We then utilize photothermal heating to release DNA from single nanomotors while measuring the temperature-dependent kinetics and activation energy of the DNA melting process. The method opens new possibilities for optomechanical quantification and application of thermally induced molecular transitions in strongly confined geometries, such as inside microfluidic devices and single cells.

Författare

Hana Sipova

Chalmers, Fysik, Bionanofotonik

Lei Shao

Chalmers, Fysik, Bionanofotonik

Nils Odebo Länk

Chalmers, Fysik, Bionanofotonik

Daniel Andrén

Chalmers, Fysik, Bionanofotonik

Mikael Käll

Chalmers, Fysik, Bionanofotonik

ACS Photonics

2330-4022 (eISSN)

Vol. 5 6 2168-2175

Ämneskategorier

Fysikalisk kemi

Atom- och molekylfysik och optik

Annan fysik

DOI

10.1021/acsphotonics.8b00034

Mer information

Senast uppdaterat

2018-08-22