Canonical DNA minor groove insertion of bisbenzamidine-Ru(ii) complexes with chiral selectivity
Artikel i vetenskaplig tidskrift, 2019

We report the first Ru(ii) coordination compounds that interact with DNA through a canonical minor groove insertion mode and with selectivity for A/T rich sites. This was made possible by integrating a bis-benzamidine minor groove DNA-binding agent with a ruthenium(ii) complex. Importantly, one of the enantiomers (Δ-[Ru(bpy)2b4bpy]2+, Δ-4Ru) shows a considerably higher DNA affinity than the parent organic ligand and the other enantiomer, particularly for the AATT sequence, while the other enantiomer preferentially targets long AAATTT sites with overall lower affinity. Finally, we demonstrate that the photophysical properties of these new binders can be exploited for DNA cleavage using visible light.


Mateo I. Sánchez

Universidade de Santiagode Compostela

Gustavo Rama

Universidade de Santiagode Compostela

Renata Calo-Lapido

Universidade de Santiagode Compostela

Kubra Ucar

Chalmers, Kemi och kemiteknik, Kemi och biokemi

Per Lincoln

Chalmers, Kemi och kemiteknik

Miguel Vázquez López

Universidade de Santiagode Compostela

Manuel Melle-Franco

Universidade de Aveiro

José L. Mascarenãs

Universidade de Santiagode Compostela

M. Eugenio Vázquez

Universidade de Santiagode Compostela

Chemical Science

2041-6520 (ISSN) 2041-6539 (eISSN)

Vol. 10 37 8668-8674


Biokemi och molekylärbiologi


Annan industriell bioteknik



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