Meta-analysis of the gut microbiota in predicting response to cancer immunotherapy in metastatic melanoma
Artikel i vetenskaplig tidskrift, 2020

BACKGROUND. Identifying factors conferring responses to therapy in cancer is critical to select the best treatment for patients. For immune checkpoint inhibition (ICI) therapy, mounting evidence suggests that the gut microbiome can determine patient treatment outcomes. However, the extent to which gut microbial features are applicable across different patient cohorts has not been extensively explored. METHODS. We performed a meta-analysis of 4 published shotgun metagenomic studies (Ntot = 130 patients) investigating differential microbiome composition and imputed metabolic function between responders and nonresponders to ICI. RESULTS. Our analysis identified both known microbial features enriched in responders, such as Faecalibacterium as the prevailing taxa, as well as additional features, including overrepresentation of Barnesiella intestinihominis and the components of vitamin B metabolism. A classifier designed to predict responders based on these features identified responders in an independent cohort of 27 patients with the area under the receiver operating characteristic curve of 0.625 (95% CI: 0.348–0.899) and was predictive of prognosis (HR = 0.35, P = 0.081). CONCLUSION. These results suggest the existence of a fecal microbiome signature inherent across responders that may be exploited for diagnostic or therapeutic purposes.


Angelo Limeta

Chalmers, Biologi och bioteknik, Systembiologi

Boyang Ji

Danmarks Tekniske Universitet (DTU)

Chalmers, Biologi och bioteknik, Systembiologi

Max Levin

Wallenberg Lab.

Sahlgrenska universitetssjukhuset

Göteborgs universitet

Francesco Gatto

Elypta AB

Chalmers, Biologi och bioteknik, Systembiologi

Jens B Nielsen

Chalmers, Biologi och bioteknik, Systembiologi

BioInnovation Institute

Danmarks Tekniske Universitet (DTU)

JCI Insight

23793708 (eISSN)

Vol. 5 23 e140940



Urologi och njurmedicin

Cancer och onkologi





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